Department of Medicine, University of Turku, Turku, Finland.
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Atherosclerosis. 2021 Nov;336:32-38. doi: 10.1016/j.atherosclerosis.2021.09.018. Epub 2021 Sep 28.
Indoleamine 2,3-dioxygenase (IDO) is an intracellular enzyme associated with artery wall inflammation. Previous studies have verified correlation between IDO activity and early signs of atherosclerosis especially in females. We aimed to elucidate the relationship between an estimate of IDO activity and atherosclerotic risk factors related to non-alchohol-fatty liver (NAFLD) in a 6- and 10-year follow-up.
Estimates of IDO activity along with complete risk factor data were measured from females (n = 506; age 24-39) and males (n = 421; age 24-39) in 2001. Risk factor measurements were conducted again in 2007 and 2011. Statistical examinations were carried out by Pearson correlation and risk ratio analysis.
In females, age-adjusted IDO correlated with body mass index (BMI) (p = 0.0008), waist (p = 0.0009), C-reactive protein (CRP) (p = 0.0014) and logarithmically modified triglycerides (p = 0.0488) in 2007. Correlation remained significant with BMI (p = 0.0007) and waist (p = 0.0063) in 2011. In males, age-adjusted IDO correlated with waist (p = 0.0367) and high-density lipoprotein cholesterol (HDL-C) (p = 0.0489) in 2007. Correlation remained significant with HDL-C (p = 0.0348) in 2011. In risk ratio analysis, relationship between IDO and obesity was confirmed in females after 10 years (RR = 1.026, p = 0.0147, 95% CI) and in males after 6 and 10 years (RR = 1.019, p = 0.0091, 95% CI and RR = 1.015, p = 0.0404, 95% CI, respectively) when the data was adjusted for age and BMI.
IDO activity correlated with obesity and factors related to NAFLD, namely obesity of visceral type, hypertriglyceridemia and CRP (in females), well-characterized risk factors for diabetes and atherosclerosis in 6- and 10-year follow-up in males and premenopausal females.
吲哚胺 2,3-双加氧酶（IDO）是一种与动脉壁炎症相关的细胞内酶。先前的研究已经证实，IDO 活性与动脉粥样硬化的早期迹象之间存在相关性，尤其是在女性中。我们旨在阐明在 6 年和 10 年的随访中，IDO 活性估计值与非酒精性脂肪肝（NAFLD）相关的动脉粥样硬化危险因素之间的关系。
在 2001 年，我们从女性（n=506；年龄 24-39 岁）和男性（n=421；年龄 24-39 岁）中测量了 IDO 活性的估计值以及完整的危险因素数据。在 2007 年和 2011 年再次进行了危险因素测量。通过 Pearson 相关性和风险比分析进行统计检验。
在女性中，经过年龄调整的 IDO 与体重指数（BMI）（p=0.0008）、腰围（p=0.0009）、C 反应蛋白（CRP）（p=0.0014）和对数化修饰的甘油三酯（p=0.0488）在 2007 年相关。在 2011 年，与 BMI（p=0.0007）和腰围（p=0.0063）的相关性仍然显著。在男性中，经过年龄调整的 IDO 与腰围（p=0.0367）和高密度脂蛋白胆固醇（HDL-C）（p=0.0489）在 2007 年相关。在 2011 年，与 HDL-C（p=0.0348）的相关性仍然显著。在风险比分析中，在女性中，IDO 与肥胖之间的关系在 10 年后得到了确认（RR=1.026，p=0.0147，95%CI），在男性中，在 6 年和 10 年后也得到了确认（RR=1.019，p=0.0091，95%CI 和 RR=1.015，p=0.0404，95%CI），当数据经过年龄和 BMI 调整时。
IDO 活性与肥胖和与 NAFLD 相关的因素相关，即女性中内脏型肥胖、高甘油三酯血症和 CRP（特征性的糖尿病和动脉粥样硬化危险因素），以及男性和绝经前女性的 6 年和 10 年随访中。
