Department of Psychiatry, Igdir State Hospital, Igdir, Turkey; Faculty of Medicine, Department of Psychiatry, Bezmialem Vakif University, Istanbul, Turkey.
Faculty of Medicine, Department of Psychiatry, Marmara University, Istanbul, Turkey.
J Affect Disord. 2022 Jan 1;296:283-290. doi: 10.1016/j.jad.2021.09.065. Epub 2021 Sep 27.
We aimed to evaluate the optical coherence tomography(OCT) findings and oxidative stress parameters in patients with bipolar disorder(BD) and their unaffected first-degree relatives(FDRs) and to explore OCT findings and oxidative stress parameters as potential endophenotype candidates.
Fifty patients with BD, 40 FDRs of BD, and 50 healthy controls(HCs) were included. OCT was performed to measure peripapillary retinal nerve fiber layer(RNFL), ganglion cell layer(GCL), inner plexiform layer(IPL), central macular, and minimum foveal thicknesses(CMT and MFT), choroidal thickness(ChT). 4-hydroxy-2-nonenal(HNE), total thiol(TT), native thiol(NT), total oxidant status(TOS), total antioxidant status(TAS), disulfide(DIS) and oxidative stress index(OSI) were measured from serum samples.
TOS was higher patients with BD and FDRs than HCs (p < .001 and p = .012, respectively). OSI, DIS, HNE levels were higher patients with BD and FDRs than HCs (p < .001). TAS, TT, NT levels were lower patients and FDRs than HCs (p < .001). MFT of patients was thinner than HCs (p = .001). CMT of patients was thinner than HCs (p = .006); the same trend was observed in FDRs but did not reach the statistical significance level (p = .07). The groups did not differ on RNFL and choroidal thickness or GCL and IPL volume.
Evaluation of only a few retinal layers.
TOS, TAS, OSI, TT, NT, DIS, HNE can be useful endophenotype biomarkers in BD. Among the OCT findings, CMT was determined as the closest parameter to being an endophenotype biomarker. Our study corroborates that oxidative stress parameters are more effective than OCT findings in endophenotype studies.
我们旨在评估双相障碍（BD）患者及其未受影响的一级亲属（FDRs）的光学相干断层扫描（OCT）结果和氧化应激参数，并探讨 OCT 结果和氧化应激参数作为潜在的表型候选者。
纳入 50 例 BD 患者、40 例 BD FDRs 和 50 例健康对照（HCs）。进行 OCT 测量以测量视盘周围视网膜神经纤维层（RNFL）、神经节细胞层（GCL）、内丛状层（IPL）、中央黄斑和最小中心凹厚度（CMT 和 MFT）、脉络膜厚度（ChT）。从血清样本中测量 4-羟基-2-壬烯醛（HNE）、总巯基（TT）、天然巯基（NT）、总氧化剂状态（TOS）、总抗氧化状态（TAS）、二硫化物（DIS）和氧化应激指数（OSI）。
BD 患者和 FDRs 的 TOS 高于 HCs（p<0.001 和 p=0.012）。BD 患者和 FDRs 的 OSI、DIS、HNE 水平高于 HCs（p<0.001）。患者和 FDRs 的 TAS、TT、NT 水平低于 HCs（p<0.001）。患者的 MFT 比 HCs 薄（p=0.001）。患者的 CMT 比 HCs 薄（p=0.006）；在 FDRs 中也观察到相同的趋势，但未达到统计学意义水平（p=0.07）。各组在 RNFL 和脉络膜厚度或 GCL 和 IPL 体积方面无差异。
仅评估了少数几个视网膜层。
TOS、TAS、OSI、TT、NT、DIS、HNE 可作为 BD 的有用表型生物标志物。在 OCT 结果中，CMT 被确定为最接近表型生物标志物的参数。我们的研究证实，氧化应激参数在表型研究中比 OCT 结果更有效。
