Department of Physiology & Pharmacology, College of Medicine & Life Sciences, University of Toledo, OH, United States.
Immunobiology. 2021 Nov;226(6):152145. doi: 10.1016/j.imbio.2021.152145. Epub 2021 Oct 1.
The 14-3-3 proteins are known for their functions related to the cell cycle and play a prominent role in cancer-related diseases. Recent studies show that 14-3-3 proteins are also regulators of immune responses and are involved in the pathogenesis of autoimmune and infectious diseases. This focused review highlights the significant and recent studies on how 14-3-3 proteins influence innate and adaptive immune responses; specifically, their roles as immunogens and cytokine signaling regulators are discussed. These revelations have added numerous questions to the pre-existing list of challenges, including understanding the 14-3-3 proteins' mechanism of immunogenicity to dissecting the isoform-specific immune regulations.
14-3-3 蛋白以其与细胞周期相关的功能而闻名，并在癌症相关疾病中发挥重要作用。最近的研究表明，14-3-3 蛋白也是免疫反应的调节剂，参与自身免疫和感染性疾病的发病机制。本综述重点介绍了关于 14-3-3 蛋白如何影响先天和适应性免疫反应的重要和最新研究；具体讨论了它们作为免疫原和细胞因子信号转导调节剂的作用。这些发现增加了许多问题，这些问题除了包括理解 14-3-3 蛋白的免疫原性机制之外，还包括剖析同种型特异性免疫调节。
