Sun Xiaomei, Ou Yongkang, Xu Yaodong
Department of Otolaryngology Head and Neck Surgery,the Sixth Affiliated Hospital of Sun Yat-sen University,Guangzhou,510655,China.
Department of Otolaryngology Head and Neck Surgery,Sun Yat-sen Memorial Hospital,Sun Yat-sen University.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Sep;35(9):825-828. doi: 10.13201/j.issn.2096-7993.2021.09.012.
To investigate the staging of vestibular organ damage in Meniere's disease, based on the vestibular function examination battery. Thirty-nine patients, clinically diagnosed as unilateral Meniere's disease, underwent audiologic test and vestibular function examination battery, including ocular vestibular evoked myogenic potential(oVEMP), cervical vestibular evoke myogenic potential(cVEMP), and caloric tests. Based on the results of the vestibular function examination battery, the vestibular function was divided into 4 stages. StageⅠ: oVEMP, cVEMP, and caloric tests were normal; stage Ⅱ: any one test of the three examinations was abnormal; stage Ⅲ: two of the three examinations were abnormal; Stage Ⅳ: All the three examinations were abnormal. According to the vestibular function staging strategy in this study, patients in stage Ⅰ, Ⅱ, Ⅲ, Ⅳ were 7.7%(3/39), 30.8%(12/39), 33.3%(13/39), 28.2%(11/39) respectively in the 39 Meniere's disease patients. However, according to the current clinical staging strategy of Meniere's disease, patients of stage1, 2, 3, 4 were 20.5%(8/39), 43.6%(17/39), 28.2%(11/39), and 7.7%(3/39) respectively. 37.5%(3/8) patients in stage 1 and 64.7%(11/17) patients in stage 2 had two or more abnormal vestibular organs. While all the patients in stage 4 had abnormal semicircular canals, utricle, and saccule. The stage of vestibular function was correlated with the distribution of current clinical staging strategy of Meniere's disease(<0.05). The combination of oVEMP, cVEMP and caloric tests can divide the vestibular function into four stages, which can be used as a supplement to the traditional vestibular evaluation and clinical staging based on audiology in Meniere's disease.
为基于前庭功能检查组合来研究梅尼埃病中前庭器官损害的分期。39例临床诊断为单侧梅尼埃病的患者接受了听力学测试和前庭功能检查组合,包括眼前庭诱发肌源性电位(oVEMP)、颈前庭诱发肌源性电位(cVEMP)和冷热试验。根据前庭功能检查组合的结果,将前庭功能分为4期。Ⅰ期:oVEMP、cVEMP和冷热试验均正常;Ⅱ期:三项检查中的任何一项异常;Ⅲ期:三项检查中的两项异常;Ⅳ期:三项检查均异常。根据本研究中的前庭功能分期策略,在39例梅尼埃病患者中,Ⅰ期、Ⅱ期、Ⅲ期、Ⅳ期的患者分别占7.7%(3/39)、30.8%(12/39)、33.3%(13/39)、28.2%(11/39)。然而,根据梅尼埃病目前的临床分期策略,1期、2期、3期、4期的患者分别占20.5%(8/39)、43.6%(17/39)、28.2%(11/39)和7.7%(3/39)。1期的37.5%(3/8)患者和2期的64.7%(11/17)患者有两个或更多异常的前庭器官。而4期的所有患者均有半规管、椭圆囊和球囊异常。前庭功能分期与梅尼埃病目前临床分期策略的分布相关(<0.05)。oVEMP、cVEMP和冷热试验的联合应用可将前庭功能分为四个阶段,可作为梅尼埃病传统前庭评估和基于听力学的临床分期的补充。