Hacettepe Üniversitesi, Faculty of Health Sciences, Audiology Department, Ankara, Turkey.
Sağlık Bilimleri Üniversitesi, Faculty of Hamidiye Health Sciences, Audiology Department, Istanbul, Turkey.
Braz J Otorhinolaryngol. 2022 Jul-Aug;88(4):556-561. doi: 10.1016/j.bjorl.2020.07.016. Epub 2020 Sep 17.
Galvanic vestibular evoked myogenic potentials evaluate vestibular nerve responses using electric stimulation by records collected from the sternocleidomastoid muscle. A normal vestibular evoked myogenic potential response consists of the first positive, P1, and negative, N1, peaks. The response can be affected by factors such as age and gender and is also consequential in the diagnosis of pathologies.
The present study was performed to obtain normative data on healthy adults, to help in diagnosis by establishing clinical norms as well as to investigate changing test parameters with age in galvanic vestibular evoked myogenic potentials.
A total of 100 healthy participants were included in the study. Galvanic vestibular evoked myogenic potential (current 3 mA, duration 1 ms) was performed randomly on both ears of each participant. The participants between the ages of 18-65 (mean age 39.7 ± 13.9) were divided into 5 groups according to their ages. Normative data of galvanic vestibular evoked myogenic potentials parameters were calculated in groups and in total, and age-related changes were examined.
The galvanic vestibular evoked myogenic potential waveform was elicited from all participants (200 ears). The latency of P1 and N1 was 7.82 ± 3.29 ms and 22.06 ± 3.95 ms, respectively. The P1-N1 amplitude value was 66.64 ± 24.5 µV. The percentage of vestibular asymmetry was 16.29 ± 11.99%. The latencies of P1 and N1 and P1-N1 amplitude values demonstrated significant differences among different age groups (p < 0.01).
The results of this study show that as age increased, latencies were prolonged, and amplitudes gradually decreased. The normative data aids in the diagnosis of retrolabyrinthine lesions and the increase in the clinical use of galvanic vestibular evoked myogenic potentials.
电刺激诱发的肌源性前庭电位通过采集胸锁乳突肌的电信号来评估前庭神经的反应。正常的电刺激诱发的肌源性前庭电位反应由第一个正相 P1 和负相 N1 波峰组成。该反应会受到年龄和性别等因素的影响，在诊断病理学方面也具有重要意义。
本研究旨在获得健康成年人的正常数据，通过建立临床正常值来帮助诊断，并研究电刺激诱发的肌源性前庭电位测试参数随年龄的变化。
本研究共纳入 100 名健康参与者。对每个参与者的双耳随机进行电刺激诱发的肌源性前庭电位（电流 3mA，持续时间 1ms）测试。参与者年龄在 18-65 岁之间（平均年龄 39.7±13.9 岁），根据年龄分为 5 组。在组内和总体上计算电刺激诱发的肌源性前庭电位参数的正常数据，并检查年龄相关的变化。
所有参与者（200 只耳朵）均引出电刺激诱发的肌源性前庭电位波形。P1 和 N1 的潜伏期分别为 7.82±3.29ms 和 22.06±3.95ms，P1-N1 波幅值为 66.64±24.5µV。前庭不对称百分比为 16.29±11.99%。不同年龄组之间 P1 和 N1 的潜伏期以及 P1-N1 波幅值均存在显著差异（p<0.01）。
本研究结果表明，随着年龄的增长，潜伏期延长，振幅逐渐降低。正常数据有助于诊断迷路后病变，并增加电刺激诱发的肌源性前庭电位的临床应用。
