头颈部鳞状细胞癌中癌症干细胞生物标志物的研究进展
[Research progress of cancer stem cell biomarkers in head and neck squamous cell carcinoma].
作者信息
Li Menglu, Gao Wei, Wu Yongyan, Guo Peiyu, Qin Yixiao, Wang Wenjing, Di Songyu, Wang Binquan
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Sep;35(9):854-858. doi: 10.13201/j.issn.2096-7993.2021.09.020.
Abstract
Cancer stem cells （CSCs）, as a few amount of tumors, have infinite replication, self-renewal, differentiation and regeneration of cell subsets with tumorigenicity, have close relationship with tumor occurrence and recurrence, which can be found in head and neck squamous cell carcinoma （HNSCC）. One of the important measures to improve the patient prognosis is monitoring cancer stem cells and timely clinical intervention. Biomarker detection of cancer stem cells is an important method for clinical monitoring of cancer stem cells. This article reviews the biomarkers of CSCs in HNSCC, which is consist of membrane surface markers, non-coding RNAs, target genes and proteins.
摘要
癌症干细胞（CSCs）作为肿瘤中的一小部分细胞亚群，具有无限增殖、自我更新、分化及再生出具有致瘤性细胞亚群的能力，与肿瘤的发生和复发密切相关，在头颈部鳞状细胞癌（HNSCC）中也可发现。改善患者预后的重要措施之一是监测癌症干细胞并及时进行临床干预。癌症干细胞的生物标志物检测是临床监测癌症干细胞的重要方法。本文综述了HNSCC中癌症干细胞的生物标志物，其包括膜表面标志物、非编码RNA、靶基因和蛋白质。
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