School of Chemistry and Chemical Engineering, Shandong University, 27 Shanda Nanlu, Jinan 250100, PR China.
National Engineering Research Center for Colloidal Materials, Shandong University, Jinan, Shandong 250100, PR China.
ACS Appl Mater Interfaces. 2021 Oct 20;13(41):49215-49223. doi: 10.1021/acsami.1c14900. Epub 2021 Oct 9.
A novel chiral separation membrane was fabricated by assembling l-cysteine (l-Cys)-modified graphene oxide sheets. l-Cys modification leads to an enantiomer separation membrane with an accessible interlayer spacing of 8 Å, which allows high solvent permeability. In the racemate separation experiments under isobaric conditions, the enantiomeric excess (ee) values of alanine (Ala), threonine (Thr), tyrosine (Tyr), and penicillamine (Pen) racemates in the permeation solution were 43.60, 44.11, 27.43, and 46.44%, respectively. In the racemate separation experiments under negative pressure, the separation performances of Ala, Thr, and Tyr were still maintained, and the enantiomeric excess (ee) values of the filtrate after separation were 56.80, 54.57, and 32.34%, respectively. These results indicate that the as-prepared GO-Cys membrane has a great practical value in the field of enantiomer separation.
一种新型的手性分离膜是通过组装 l-半胱氨酸（l-Cys）修饰的氧化石墨烯片制备的。l-Cys 修饰导致具有可及层间距为 8 Å 的对映体分离膜，其具有高溶剂透过率。在等压条件下的外消旋体分离实验中，渗透溶液中丙氨酸（Ala）、苏氨酸（Thr）、酪氨酸（Tyr）和青霉胺（Pen）外消旋体的对映体过量（ee）值分别为 43.60、44.11、27.43 和 46.44%。在负压下的外消旋体分离实验中，Ala、Thr 和 Tyr 的分离性能仍然保持，分离后滤液的对映体过量（ee）值分别为 56.80、54.57 和 32.34%。这些结果表明，所制备的 GO-Cys 膜在手性分离领域具有很大的实用价值。
