Department of Gynecologic Oncology, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Ann Palliat Med. 2021 Sep;10(9):9544-9552. doi: 10.21037/apm-21-1974.
The purpose of this study is to investigate the correlation between cytokeratin 7 (CK7) and marker of proliferation Ki67 protein expression and clinical characteristics and prognosis of patients with cervical adenocarcinoma after surgery.
A total of 126 patients with cervical adenocarcinoma treated by surgery in our hospital from June 2011 to September 2015 were enrolled in this study. Immunohistochemistry (IHC) was used to detect the expression of CK7 and Ki67 in 126 cases of cervical adenocarcinoma tissues. The chi-square (χ2) test was used to compare the relationship between the positive expression rate of CK7 or Ki67 and clinicopathological features. Kaplan-Meier method was used to analyze the survival of different protein expression groups and Cox proportional hazards regression model was used to analyze the risk factors affecting the prognosis.
The positive rate of CK7 was correlated with muscle invasion, vascular invasion, differentiation, and lymph node metastasis (all P<0.05). The positive expression rate of Ki67 was related to the degree of myometrial invasion and International Federation of Gynecology and Obstetrics (FIGO) stage (both P<0.05). Both CK7 and Ki67 may be independent risk factors for the prognosis of patients with cervical adenocarcinoma after surgery (both P<0.05), and their high expression heralds worse prognosis.
The CK7 and Ki67 proteins may be key regulatory factors in the development of cervical adenocarcinoma after surgery, and their overexpression may lead to worse prognosis. Both CK7 and Ki67 may provide new markers for prognosis evaluation of cervical adenocarcinoma.
本研究旨在探讨细胞角蛋白 7（CK7）和增殖标志物 Ki67 蛋白表达与手术后宫颈腺癌患者临床特征和预后的相关性。
选取我院 2011 年 6 月至 2015 年 9 月间手术治疗的 126 例宫颈腺癌患者，采用免疫组化（IHC）检测 126 例宫颈腺癌组织中 CK7 和 Ki67 的表达，采用卡方（χ2）检验比较 CK7 或 Ki67 阳性表达率与临床病理特征的关系，采用 Kaplan-Meier 法分析不同蛋白表达组的生存情况，采用 Cox 比例风险回归模型分析影响预后的危险因素。
CK7 的阳性率与肌层浸润、血管浸润、分化和淋巴结转移有关（均 P<0.05）。Ki67 的阳性表达率与肌层浸润程度和国际妇产科联盟（FIGO）分期有关（均 P<0.05）。CK7 和 Ki67 均可能是宫颈腺癌患者手术后预后的独立危险因素（均 P<0.05），其高表达预示预后较差。
CK7 和 Ki67 蛋白可能是手术后宫颈腺癌发生发展的关键调节因子，其过表达可能导致预后不良。CK7 和 Ki67 均可为宫颈腺癌的预后评估提供新的标志物。
