Kumar Amit, Siwach Ankit, Verma Prabhakar
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana 124001, India.
Mini Rev Med Chem. 2022;22(6):884-903. doi: 10.2174/1389557521666211008153329.
Pyrimidine and its derivatives are a very important class of heterocyclic compounds that show interesting applications in the field of medicinal chemistry. Pyrimidine not only plays an important role as an organic reaction intermediate but also has a wide range of interesting biological activities viz. antibacterial, antifungal, anticancer, anti-inflammatory, antiviral, and antiprotozoal activities, etc. Numerous methods are available for the formation of pyrimidine derivatives that have been reported in the literature. The advantage of pyrimidine as a starting material for different therapeutically potent derivatives has given momentum to this research. This review aims to report the new work on the synthesis of marketed drugs which consist pyrimidine moiety.
嘧啶及其衍生物是一类非常重要的杂环化合物，在药物化学领域有着有趣的应用。嘧啶不仅作为有机反应中间体发挥着重要作用，还具有广泛的有趣生物活性，即抗菌、抗真菌、抗癌、抗炎、抗病毒和抗原虫活性等。文献中报道了许多形成嘧啶衍生物的方法。嘧啶作为不同治疗活性衍生物的起始原料的优势推动了这项研究。本综述旨在报道含嘧啶部分的市售药物合成方面的新工作。
