Sbeit Wisam, Khoury Tawfik
Pancreas. 2021 Aug 1;50(7):990-993. doi: 10.1097/MPA.0000000000001867.
Fatty pancreas (FP), previously believed to be without clinical significance, recently has been shown to be associated with comorbid diseases. We aimed to explore whether FP predispose to acute pancreatitis.
Patients who underwent endoscopic ultrasound for hepatobiliary indications were included. Patients with pathological pancreato-biliary findings other than FP were excluded. The cohort was divided into patients with a history of pancreatitis (within 6 months of endoscopic ultrasound, group A) and patients without (group B).
Overall, 189 patients were included. Sixty-one (32.3%) patients were in group A, and 128 (67.7%) patients were in group B. The average age in group A was 55.5 (standard deviation, 17.7) versus 58.5 (standard deviation, 13.5) in group B. The prevalence of FP in group A (37.7%) was higher compared with group B (4.7%) (P = 0.001). On univariate analysis, FP showed significant correlation with a history of acute pancreatitis [odds ratio (OR), 5.14, P = 0.006] and hyperlipidemia (OR, 4.19; P = 0.002). On multivariate analysis, FP remained significantly associated with a history of acute pancreatitis after stratification for obesity and hyperlipidemia (OR, 10.78; 95% confidence interval, 3.75-30.89; P < 0.0001).
Fatty pancreas was associated with acute pancreatitis. Clinicians should be aware of this association.
脂肪性胰腺（FP）以前被认为无临床意义，最近已被证明与合并症有关。我们旨在探讨FP是否易患急性胰腺炎。
纳入因肝胆疾病指征接受内镜超声检查的患者。排除有除FP以外的病理性胰胆发现的患者。该队列分为有胰腺炎病史的患者（在内镜超声检查后6个月内，A组）和无胰腺炎病史的患者（B组）。
总体上，纳入了189例患者。A组有61例（32.3%）患者，B组有128例（67.7%）患者。A组的平均年龄为55.5岁（标准差，17.7），而B组为58.5岁（标准差，13.5）。A组中FP的患病率（37.7%）高于B组（4.7%）（P = 0.001）。单因素分析显示，FP与急性胰腺炎病史[比值比（OR），5.14，P = 0.006]和高脂血症（OR，4.19；P = 0.002）显著相关。多因素分析显示，在对肥胖和高脂血症进行分层后，FP仍与急性胰腺炎病史显著相关（OR，10.78；95%置信区间，3.75 - 30.89；P < 0.0001）。
脂肪性胰腺与急性胰腺炎有关。临床医生应意识到这种关联。
