Pancreatic Center, Department of Gastroenterology, Yangzhou Key Laboratory of Pancreatic Disease, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China.
Department of Gastroenterology, Kunshan Hospital of Traditional Chinese Medicine, Suzhou Key Laboratory of Integrated Traditional Chinese and Western Medicine of Digestive Diseases, Kunshan Affiliated Hospital of Yangzhou University, Kunshan, China.
Am J Gastroenterol. 2024 Jun 1;119(6):1158-1166. doi: 10.14309/ajg.0000000000002792. Epub 2024 Apr 8.
To investigate whether increased intrapancreatic fat deposition (IPFD) heightens the risk of diseases of the exocrine and endocrine pancreas.
A prospective cohort study was conducted using data from the UK Biobank. IPFD was quantified using MRI and a deep learning-based framework called nnUNet. The prevalence of fatty change of the pancreas (FP) was determined using sex- and age-specific thresholds. Associations between IPFD and pancreatic diseases were assessed with multivariate Cox-proportional hazard model adjusted for age, sex, ethnicity, body mass index, smoking and drinking status, central obesity, hypertension, dyslipidemia, liver fat content, and spleen fat content.
Of the 42,599 participants included in the analysis, the prevalence of FP was 17.86%. Elevated IPFD levels were associated with an increased risk of acute pancreatitis (hazard ratio [HR] per 1 quintile change 1.513, 95% confidence interval [CI] 1.179-1.941), pancreatic cancer (HR per 1 quintile change 1.365, 95% CI 1.058-1.762) and diabetes mellitus (HR per 1 quintile change 1.221, 95% CI 1.132-1.318). FP was also associated with a higher risk of acute pancreatitis (HR 3.982, 95% CI 2.192-7.234), pancreatic cancer (HR 1.976, 95% CI 1.054-3.704), and diabetes mellitus (HR 1.337, 95% CI 1.122-1.593, P = 0.001).
FP is a common pancreatic disorder. Fat in the pancreas is an independent risk factor for diseases of both the exocrine pancreas and endocrine pancreas.
本研究旨在探究胰内脂肪沉积（IPFD）增加是否会增加外分泌和内分泌胰腺疾病的风险。
本研究采用 UK Biobank 的数据进行前瞻性队列研究。使用 MRI 和称为 nnUNet 的深度学习框架来量化 IPFD。使用基于性别和年龄的阈值来确定胰腺脂肪变性（FP）的患病率。使用多变量 Cox 比例风险模型评估 IPFD 与胰腺疾病之间的关联，该模型调整了年龄、性别、种族、体重指数、吸烟和饮酒状况、中心性肥胖、高血压、血脂异常、肝脂肪含量和脾脂肪含量等因素。
在纳入分析的 42599 名参与者中，FP 的患病率为 17.86%。IPFD 水平升高与急性胰腺炎的风险增加相关（每五分位变化的 HR 为 1.513，95%CI 为 1.179-1.941）、胰腺癌（HR 每五分位变化 1.365，95%CI 为 1.058-1.762）和糖尿病（HR 每五分位变化 1.221，95%CI 为 1.132-1.318）。FP 也与急性胰腺炎（HR 3.982，95%CI 2.192-7.234）、胰腺癌（HR 1.976，95%CI 1.054-3.704）和糖尿病（HR 1.337，95%CI 1.122-1.593，P = 0.001）的风险增加相关。
FP 是一种常见的胰腺疾病。胰腺脂肪是外分泌和内分泌胰腺疾病的独立危险因素。
