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接受原发性化疗的乳腺癌患者碳标记后腋窝淋巴结的靶向清除

Targeted Removal of Axillary Lymph Nodes After Carbon Marking in Patients with Breast Cancer Treated with Primary Chemotherapy.

作者信息

Hartmann Steffi, Stachs Angrit, Kühn Thorsten, de Boniface Jana, Banys-Paluchowski Maggie, Reimer Toralf

机构信息

Universitätsklinikum Rostock, Klinik für Gynäkologie und Geburtshilfe, Rostock, Germany.

Klinikum Esslingen, Klinik für Gynäkologie und Geburtshilfe, Esslingen, Germany.

出版信息

Geburtshilfe Frauenheilkd. 2021 Oct;81(10):1121-1127. doi: 10.1055/a-1471-4234. Epub 2021 Oct 6.

DOI:10.1055/a-1471-4234
PMID:34629491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8494517/
Abstract

In breast cancer patients who have received primary chemotherapy and then no longer have any suspicious lymph nodes clinically and/or on imaging, marking of initially suspicious axillary lymph nodes with targeted removal has recently been discussed and practised both in Germany and internationally as an alternative to complete axillary lymph node dissection. Tattooing of the suspicious lymph nodes with a highly purified carbon suspension is currently being investigated in clinical studies. Compared with other techniques, the advantages of this method are the high rate of intraoperative lymph node detection, avoidance of an immediately preoperative localisation procedure and the low costs. The practical aspects of lymph node tattooing and the current data regarding this method will be described.

摘要

在接受过原发性化疗且临床上和/或影像学检查均不再有任何可疑淋巴结的乳腺癌患者中,对最初可疑的腋窝淋巴结进行标记并针对性切除,最近在德国和国际上都已被讨论并实践,作为完全腋窝淋巴结清扫术的一种替代方法。目前临床研究正在调查使用高纯度碳悬浮液对可疑淋巴结进行纹身。与其他技术相比,该方法的优点是术中淋巴结检出率高、避免术前立即进行定位程序且成本低。将描述淋巴结纹身的实际操作方面以及有关该方法的当前数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/fbedd70b8342/10-1055-a-1471-4234-igfde04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/3158296ea574/10-1055-a-1471-4234-igf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/2ebe03fb8455/10-1055-a-1471-4234-igf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/5e04bbd40c7b/10-1055-a-1471-4234-igf03ab.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/fbedd70b8342/10-1055-a-1471-4234-igf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/3158296ea574/10-1055-a-1471-4234-igfde01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/2ebe03fb8455/10-1055-a-1471-4234-igfde02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/5e04bbd40c7b/10-1055-a-1471-4234-igfde03ab.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/fbedd70b8342/10-1055-a-1471-4234-igfde04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/3158296ea574/10-1055-a-1471-4234-igf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/2ebe03fb8455/10-1055-a-1471-4234-igf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/5e04bbd40c7b/10-1055-a-1471-4234-igf03ab.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/fbedd70b8342/10-1055-a-1471-4234-igf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/3158296ea574/10-1055-a-1471-4234-igfde01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/2ebe03fb8455/10-1055-a-1471-4234-igfde02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/5e04bbd40c7b/10-1055-a-1471-4234-igfde03ab.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d83/8494517/fbedd70b8342/10-1055-a-1471-4234-igfde04.jpg

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本文引用的文献

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How Often Does Retrieval of a Clipped Lymph Node Change Adjuvant Therapy Recommendations? A Prospective, Consecutive, Patient Cohort Study.夹闭淋巴结的检出频率会改变辅助治疗建议吗?一项前瞻性、连续、患者队列研究。
Ann Surg Oncol. 2022 Jun;29(6):3764-3771. doi: 10.1245/s10434-022-11324-7. Epub 2022 Jan 18.
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Carbon tattooing for targeted lymph node biopsy after primary systemic therapy in breast cancer: prospective multicentre TATTOO trial.乳腺癌原发全身治疗后行靶向性前哨淋巴结活检的碳染色法:前瞻性多中心 TATTOO 试验。
Br J Surg. 2021 Apr 5;108(3):302-307. doi: 10.1093/bjs/znaa083.
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A Prospective, Multicenter Registry Study to Evaluate the Clinical Feasibility of Targeted Axillary Dissection (TAD) in Node-positive Breast Cancer Patients.
Applicability of magnetic seeds for target lymph node biopsy after neoadjuvant chemotherapy in initially node-positive breast cancer patients: data from the AXSANA study.磁性种子在新辅助化疗后初始淋巴结阳性乳腺癌患者目标淋巴结活检中的适用性:来自AXSANA研究的数据。
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Image-Guided Localization Techniques for Metastatic Axillary Lymph Nodes in Breast Cancer; What Radiologists Should Know.乳腺癌腋窝转移性淋巴结的图像引导定位技术;放射科医生应了解的内容。
Cancers (Basel). 2023 Apr 3;15(7):2130. doi: 10.3390/cancers15072130.
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Axillary Staging after Neoadjuvant Chemotherapy for Initially Node-Positive Breast Carcinoma in Germany: Initial Data from the AXSANA study.德国新辅助化疗后初始淋巴结阳性乳腺癌的腋窝分期:AXSANA研究的初步数据。
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