Tekel Masho Tigabe, Bekalu Abaynesh Fentahun, Sema Faisel Dula
Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Adv Med Educ Pract. 2021 Oct 2;12:1129-1139. doi: 10.2147/AMEP.S327739. eCollection 2021.
The adequate knowledge, attitude, and practice (KAP) of pharmacovigilance and ADRs reporting is crucial for health care students.
This study aimed at assessing the KAP of final-year medical, pharmacy, and nursing (MPN) students towards pharmacovigilance and ADRs reporting at the University of Gondar, College of Medicine and Health Sciences, Northwest Ethiopia.
A cross-sectional study was conducted among 296 final-year MPN students at the University of Gondar College of Medicine and Health Sciences from November 1, 2020 to January 30, 2021. A close-ended, structured, self-administered questionnaire was used for data collection prospectively. SPSS (IBM Corporation) version 24 was used to analyze the data with descriptive and inferential statistics. The comparison of the KAP of groups was made by using a Kruskal-Wallis test and Mann-Whitney -test. Statistical significance was declared at a p-value < 0.05.
Among 296 participants, the majority of them had a poor level of knowledge (69.9%), practice (95.9%), and moderate attitude (62.5%) towards pharmacovigilance and ADRs reporting. The median (interquartile range) score of the students' knowledge (maximum score = 15), attitude (maximum score = 50), and practice (maximum score = 5) towards PV and ADR reporting was 6 (5-8), 32 (28.25-35), and 1 (0-1), respectively. The KAP of the students has shown differences with age, sex, hearing of the term PV, and discipline. A lack of training on ADRs (49%) reporting and not knowing where and how to report ADRs (47.3%) were among the main reasons of MPN students for not reporting ADRs.
A majority of final-year MPN students had poor knowledge, practice, and a moderate attitude towards PV and ADRs reporting. The school of medicine, pharmacy, and nursing should adequately cover the issue of PV and ADRs reporting in the undergraduate curriculum.
药物警戒和药品不良反应报告方面的充分知识、态度和实践（KAP）对医学生至关重要。
本研究旨在评估埃塞俄比亚西北部贡德尔大学医学与健康科学学院最后一年医学、药学和护理（MPN）专业学生对药物警戒和药品不良反应报告的KAP。
2020年11月1日至2021年1月30日，在贡德尔大学医学与健康科学学院对296名最后一年MPN专业学生进行了一项横断面研究。前瞻性地使用封闭式、结构化、自填式问卷进行数据收集。使用SPSS（IBM公司）24版进行描述性和推断性统计分析数据。采用Kruskal-Wallis检验和Mann-Whitney检验对各组的KAP进行比较。p值<0.05时具有统计学意义。
在296名参与者中，大多数人对药物警戒和药品不良反应报告的知识水平较差（69.9%）、实践水平较差（95.9%）、态度中等（62.5%）。学生对药物警戒和药品不良反应报告的知识（满分 = 15分）中位数（四分位间距）得分、态度（满分 = 50分）得分和实践（满分 = 5分）得分分别为6（5 - 8）、32（28.25 - 35）和l（0~1）。学生的KAP在年龄、性别、是否听说过药物警戒术语以及学科方面存在差异。MPN专业学生不报告药品不良反应的主要原因包括缺乏药品不良反应报告培训（49%）以及不知道在哪里以及如何报告药品不良反应（47.3%）。
大多数最后一年MPN专业学生对药物警戒和药品不良反应报告的知识和实践较差，态度中等。医学、药学和护理学院应在本科课程中充分涵盖药物警戒和药品不良反应报告问题。
