Pharmacy, Nepal Cancer Hospital and Research Center, Harisidhhi, Lalitpur, Nepal.
Clinical Pharmacy Unit, Nepal Cancer Hospital and Research Center, Harisidhhi, Lalitpur, Nepal.
BMC Med Educ. 2020 Jun 3;20(1):179. doi: 10.1186/s12909-020-02084-7.
Pharmacovigilance (PV) knowledge and attitudes among health care professionals (HCPs) directly affect the practice of PV and reporting of adverse drug reactions (ADRs) in a hospital. The main aim of the study was to assess the impact of an education intervention on the knowledge and attitude of HCPs attached to the regional PV center in an oncology based hospital of Nepal.
A pre-post intervention questionnaire-based study was conducted amongst HCPs, i.e. nurses and pharmacists of an oncology based hospital of Nepal. A 21-item pretested PV questionnaire (twelve and four statements for assessing knowledge and attitude respectively) was used before and after an educational intervention among 89 HCPs working in the hospital. SPSS version 21.0 was used to analyze pre- and post-survey data with descriptive and inferential statistics. The knowledge and attitude scores before and after educational intervention were analyzed with Wilcoxon rank-sum test.
After the educational intervention, the mean score for knowledge about PV and ADR increased from [mean ± S.D] 6.90 ± 2.527 (pre-test) to 11.36 ± 1.189 (post-test, p < 0.001). There were significant improvements after an educational intervention in attitude from 1.80 ± 0.932 (pre-test) to 3.61 ± 0.556 (post-test, p < 0.001). Twenty-one (23.6%) of participants responded that they lacked the time to report ADR, while 12 (13.5%) replied that there was no remuneration for reporting ADR. Approximately 24% of them recommended frequent pharmacovigilance awareness programs via continuing medical education or other similar kinds of workshops for improvement of pharmacovigilance.
The preliminary findings of this study showed that knowledge and attitude scores were increased following an educational intervention. They also suggested that training on PV and ADR tends to have a positive impact on knowledge and attitude among nurses and pharmacists working at an oncology based hospital in Nepal.
药物警戒（PV）知识和态度直接影响医疗保健专业人员（HCP）的实践以及医院内不良药物反应（ADR）的报告。本研究的主要目的是评估教育干预对尼泊尔一家肿瘤医院区域 PV 中心附属 HCP 的知识和态度的影响。
在尼泊尔一家肿瘤医院，对 HCP（护士和药剂师）进行了一项基于问卷调查的干预前后研究。在对 89 名在医院工作的 HCP 进行教育干预之前和之后，使用了一份经过预先测试的 21 项 PV 问卷（分别有 12 项和 4 项陈述用于评估知识和态度）。使用 SPSS 版本 21.0 对预调查和调查后数据进行描述性和推断性统计分析。使用 Wilcoxon 秩和检验分析教育干预前后的知识和态度评分。
教育干预后，PV 和 ADR 知识的平均得分从[平均值±S.D]6.90±2.527（预测试）增加到 11.36±1.189（后测试，p<0.001）。在态度方面，经过教育干预后，从 1.80±0.932（预测试）显著提高到 3.61±0.556（后测试，p<0.001）。21（23.6%）名参与者表示他们缺乏报告 ADR 的时间，而 12（13.5%）名参与者表示报告 ADR 没有报酬。他们中约有 24%的人建议通过继续医学教育或其他类似的研讨会频繁开展药物警戒意识计划，以提高药物警戒能力。
本研究的初步结果表明，教育干预后知识和态度得分有所提高。他们还表明，在尼泊尔的一家肿瘤医院，针对 PV 和 ADR 的培训对护士和药剂师的知识和态度具有积极影响。
