Jiang Xuye, Gu Yingying, Huang Yuanling, Zhou Yujia, Pang Nengzhi, Luo Jing, Tang Zhaoyang, Zhang Zhenfeng, Yang Lili
Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, China.
Department of Nutrition, Binhaiwan Central Hospital of Dongguan, The Dongguan Affiliated Hospital of Medical College of Jinan University, Dongguan, China.
Front Pharmacol. 2021 Sep 22;12:724747. doi: 10.3389/fphar.2021.724747. eCollection 2021.
Alcohol abuse and high-fat diet-induced liver diseases have been the most prevalent chronic liver diseases and the leading reasons for liver transplantation around the world. Cannabidiol (CBD) is a botanical component extracted from marijuana plants without psychoactive impact. In our previous reports, we found that CBD can prevent fatty liver induced by Lieber-DeCarli ethanol diet or non-alcoholic fatty liver disease (NAFLD) induced by high-fat high-cholesterol diet. The current work is a further study on whether CBD can alleviate liver injuries induced by ethanol plus high-fat high-cholesterol diet (EHFD), which is a model simulating heavy alcohol drinkers in a Western diet. A mice liver injury model induced by EHFD for 8 weeks was applied to explore the protective properties of CBD and the underlying mechanisms. We found that CBD prevented liver steatosis and oxidative stress induced by EHFD. CBD treatment inhibited macrophage recruitment and suppressed activation of NFκB-NLRP3-pyroptosis pathway in mice livers. The hepatoprotective property of CBD in the current model might be a result of inhibition of inflammation via alleviating activation of the hepatic NFκB-NLRP3 inflammasome-pyroptosis pathway by CBD.
酒精滥用和高脂饮食引起的肝脏疾病一直是全球最普遍的慢性肝脏疾病，也是肝脏移植的主要原因。大麻二酚（CBD）是从大麻植物中提取的一种无精神活性影响的植物成分。在我们之前的报告中，我们发现CBD可以预防由利伯-德卡利乙醇饮食诱导的脂肪肝或由高脂高胆固醇饮食诱导的非酒精性脂肪性肝病（NAFLD）。目前的工作是进一步研究CBD是否可以减轻由乙醇加高脂高胆固醇饮食（EHFD）诱导的肝损伤，EHFD是一种模拟西方饮食中重度饮酒者的模型。应用由EHFD诱导8周的小鼠肝损伤模型来探索CBD的保护特性及其潜在机制。我们发现CBD可预防EHFD诱导的肝脏脂肪变性和氧化应激。CBD治疗可抑制巨噬细胞募集并抑制小鼠肝脏中NFκB-NLRP3-焦亡途径的激活。在当前模型中，CBD的肝脏保护特性可能是通过减轻CBD对肝脏NFκB-NLRP3炎性小体-焦亡途径的激活来抑制炎症的结果。
