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骨髓间充质干细胞来源外泌体对椎间盘及骨骼外器官的跨器官调控研究

Study on Transorgan Regulation of Intervertebral Disc and Extra-Skeletal Organs Through Exosomes Derived From Bone Marrow Mesenchymal Stem Cells.

作者信息

Wang Zhikun, Wu Yangming, Zhao Zhonghan, Liu Chengyi, Zhang Lingli

机构信息

School of Kinesiology, Shanghai University of Sport, Shanghai, China.

School of Physical Education and Sports Science, South China Normal University, Guangzhou, China.

出版信息

Front Cell Dev Biol. 2021 Sep 23;9:741183. doi: 10.3389/fcell.2021.741183. eCollection 2021.

DOI:10.3389/fcell.2021.741183
PMID:34631718
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8495158/
Abstract

Exosomes are membranous lipid vesicles fused with intracellular multicellular bodies and then released into the extracellular environment. They contain various bioactive substances, including proteins, mRNA, miRNAs, lncRNAs, circRNAs, lipids, transcription factors, and cytokine receptors. Under certain conditions, bone marrow mesenchymal stem cells (BMSCs) can differentiate into osteoblasts, chondrocytes, adipocytes, and biological functions. This study provides a theoretical basis for the application of exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exos) in osteology, exploring different sources of exosomes to improve bone microenvironment and resist bone metastasis. We also provided new ideas for the prevention and rehabilitation of human diseases by exosomes.

摘要

外泌体是与细胞内多泡体融合后释放到细胞外环境中的膜性脂质囊泡。它们含有多种生物活性物质，包括蛋白质、mRNA、miRNA、lncRNA、circRNA、脂质、转录因子和细胞因子受体。在某些条件下，骨髓间充质干细胞（BMSCs）可分化为成骨细胞、软骨细胞、脂肪细胞并发挥生物学功能。本研究为骨髓间充质干细胞来源的外泌体（BMSC-Exos）在骨科学中的应用提供了理论依据，探索不同来源的外泌体以改善骨微环境并抵抗骨转移。我们还为外泌体预防和治疗人类疾病提供了新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b33/8495158/5b386e4af273/fcell-09-741183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b33/8495158/1bd97102b4d6/fcell-09-741183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b33/8495158/b04ade87cca3/fcell-09-741183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b33/8495158/5b386e4af273/fcell-09-741183-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b33/8495158/1bd97102b4d6/fcell-09-741183-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b33/8495158/b04ade87cca3/fcell-09-741183-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b33/8495158/5b386e4af273/fcell-09-741183-g003.jpg

相似文献

[1]
Study on Transorgan Regulation of Intervertebral Disc and Extra-Skeletal Organs Through Exosomes Derived From Bone Marrow Mesenchymal Stem Cells.

Front Cell Dev Biol. 2021-9-23

[2]
Exosome mediated biological functions within skeletal microenvironment.

Front Bioeng Biotechnol. 2022-7-22

[3]
Exosomes secreted from mutant-HIF-1α-modified bone-marrow-derived mesenchymal stem cells attenuate early steroid-induced avascular necrosis of femoral head in rabbit.

Cell Biol Int. 2017-12

[4]
Exosomal miR-532-5p from bone marrow mesenchymal stem cells reduce intervertebral disc degeneration by targeting RASSF5.

Exp Cell Res. 2020-8-15

[5]
Exosomes derived from mesenchymal stem cells inhibit mitochondrial dysfunction-induced apoptosis of chondrocytes via p38, ERK, and Akt pathways.

In Vitro Cell Dev Biol Anim. 2019-3

[6]
Exosomes Derived from miR-214-Enriched Bone Marrow-Derived Mesenchymal Stem Cells Regulate Oxidative Damage in Cardiac Stem Cells by Targeting CaMKII.

Oxid Med Cell Longev. 2018-8-7

[7]
Impaired Bone Regenerative Effect of Exosomes Derived from Bone Marrow Mesenchymal Stem Cells in Type 1 Diabetes.

Stem Cells Transl Med. 2019-2-26

[8]
Exosomes derived from miRNA-210 overexpressing bone marrow mesenchymal stem cells protect lipopolysaccharide induced chondrocytes injury via the NF-κB pathway.

Gene. 2020-5-16

[9]
LncRNA MALAT1 shuttled by bone marrow-derived mesenchymal stem cells-secreted exosomes alleviates osteoporosis through mediating microRNA-34c/SATB2 axis.

Aging (Albany NY). 2019-10-26

[10]
microRNA-935-modified bone marrow mesenchymal stem cells-derived exosomes enhance osteoblast proliferation and differentiation in osteoporotic rats.

Life Sci. 2021-5-1

引用本文的文献

[1]
Different exosomes are loaded in hydrogels for the application in the field of tissue repair.

Front Bioeng Biotechnol. 2025-3-3

[2]
LncRNA SNHG14 Delivered by Bone Marrow Mesenchymal Stem Cells-Secreted Exosomes Regulates Osteogenesis and Adipogenesis in Osteoporosis by Mediating the miR-27a-3p/LMNB1 Axis.

Kaohsiung J Med Sci. 2025-5

[3]
Exosome-loaded tannic acid-thioctic acid hydrogel enhances wound healing in coagulation disorders.

Mater Today Bio. 2025-1-24

[4]
Roles, Functions, and Pathological Implications of Exosomes in the Central Nervous System.

Int J Mol Sci. 2025-2-5

[5]
Regenerative properties of bone marrow mesenchymal stem cell derived exosomes in rotator cuff tears.

J Transl Med. 2025-1-12

[6]
Adipose Mesenchymal Stem Cell-Derived Exosomes as Nanocarriers for Treating Musculoskeletal Disorders.

Int J Nanomedicine. 2024-12-19

[7]
Mesenchymal stem cell-derived extracellular vesicles for human diseases.

Extracell Vesicles Circ Nucl Acids. 2024-2-6

[8]
Thread-structural microneedles loaded with engineered exosomes for annulus fibrosus repair by regulating mitophagy recovery and extracellular matrix homeostasis.

Bioact Mater. 2024-3-13

[9]
Bone marrow mesenchymal stem cell‑derived exosomes: A novel therapeutic agent for tendon‑bone healing (Review).

Int J Mol Med. 2023-12

[10]
Association between gut microbiota and bone metabolism: Insights from bibliometric analysis.

Front Physiol. 2023-4-19

本文引用的文献

[1]
BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A-YAP axis.

Acta Pharmacol Sin. 2021-12

[2]
Treatment for Hepatocellular Carcinoma Is Enhanced When Norcantharidin Is Encapsulated in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells.

Mol Pharm. 2021-3-1

[3]
lncRNA-CRNDE regulates BMSC chondrogenic differentiation and promotes cartilage repair in osteoarthritis through SIRT1/SOX9.

Mol Cell Biochem. 2021-4

[4]
Exosomes from microRNA-126 overexpressing mesenchymal stem cells promote angiogenesis by targeting the PIK3R2-mediated PI3K/Akt signalling pathway.

J Cell Mol Med. 2021-2

[5]
Exosomes from 3D culture of marrow stem cells enhances endothelial cell proliferation, migration, and angiogenesis via activation of the HMGB1/AKT pathway.

Stem Cell Res. 2020-12-10

[6]
Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.

Cell Biol Int. 2021-4

[7]
Exosomes Derived from Bone Mesenchymal Stem Cells with the Stimulation of FeO Nanoparticles and Static Magnetic Field Enhance Wound Healing Through Upregulated miR-21-5p.

Int J Nanomedicine. 2020-10-19

[8]
Exosomes Derived from MicroRNA-146a-5p-Enriched Bone Marrow Mesenchymal Stem Cells Alleviate Intracerebral Hemorrhage by Inhibiting Neuronal Apoptosis and Microglial M1 Polarization.

Drug Des Devel Ther. 2020-8-5

[9]
Schwann Cell-derived exosomes promote bone regeneration and repair by enhancing the biological activity of porous Ti6Al4V scaffolds.

Biochem Biophys Res Commun. 2020-10-22

[10]
Human Bone Marrow Mesenchymal Stem Cell-derived Exosomes Attenuate IL-1β-induced Annulus Fibrosus Cell Damage.

Am J Med Sci. 2020-7-20

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