Investigations on the effect of metamizol on ureteral motility.

The aim of this comparative study was to obtain quantitative information on the effect that metamizol has on ureteral motility. Renal Tc-99m-MDP excretion and ureteral urine transport against gravity were examined in five patients, once without (control) and, several days later, with metamizol treatment. In each of these ten scanning sessions, renograms of both kidneys were recorded. They were corrected for background activity and compared with respect to the following parameters: the curve amplitude at 30 min p.i. normalized to the respective maximum amplitude; the 6-30 min and 40 s-6 min integrals of a corrected curve. Under metamizol medication, the flow of radioactivity to the bladder was thus found to be significantly reduced (p less than 0.001). The comparison of the Tc-99m-MDP retention curves obtained with and without metamizol treatment did not reveal a statistically significant drug effect on renal Tc-99m-MDP excretion.