Schroth H J, Steinsträsser A, Berberich R, Kloss G
Agents Actions Suppl. 1986;19:177-88.
The aim of this comparative study was to obtain quantitative information on the effect that metamizol has on ureteral motility. Renal Tc-99m-MDP excretion and ureteral urine transport against gravity were examined in five patients, once without (control) and, several days later, with metamizol treatment. In each of these ten scanning sessions, renograms of both kidneys were recorded. They were corrected for background activity and compared with respect to the following parameters: the curve amplitude at 30 min p.i. normalized to the respective maximum amplitude; the 6-30 min and 40 s-6 min integrals of a corrected curve. Under metamizol medication, the flow of radioactivity to the bladder was thus found to be significantly reduced (p less than 0.001). The comparison of the Tc-99m-MDP retention curves obtained with and without metamizol treatment did not reveal a statistically significant drug effect on renal Tc-99m-MDP excretion.
这项对比研究的目的是获取关于安乃近对输尿管蠕动影响的定量信息。对5名患者进行了肾Tc-99m-MDP排泄及输尿管逆重力尿液输送的检查，一次是在未使用（对照）安乃近的情况下，几天后则是在使用安乃近治疗的情况下。在这10次扫描过程中，每次都记录了双肾的肾图。对其本底活性进行了校正，并就以下参数进行了比较：注射后30分钟时的曲线幅度，以各自的最大幅度进行归一化处理；校正曲线的6 - 30分钟和40秒 - 6分钟积分。结果发现，在使用安乃近药物治疗期间，放射性物质向膀胱的流动显著减少（p < 0.001）。对比使用和未使用安乃近治疗时获得的Tc-99m-MDP滞留曲线，未发现该药物对肾Tc-99m-MDP排泄有统计学意义上的显著影响。
