Rohdewald P, Drehsen G, Milsmann E, Derendorf H
Arzneimittelforschung. 1983;33(7):985-8.
Salivary levels of the metabolites of metamizol (N-methyl-, N-acetyl- and 4-aminoantipyrine) were determined after the intake of film-coated metamizol (Novalgin) tablets and metamizol (Novalgin) solution. Cortical evoked potentials, pain ratings and thresholds of sensation were monitored following tooth pulp stimulation after administration of metamizol tablets. Within the different groups of subjects a remarkable degree of reproducibility was obtained for the metabolite concentrations in saliva. At 20 min after drug intake a more rapid absorption was demonstrable for the solution in comparison to the tablets. The metabolite levels were correlated to the simultaneously recorded pain response demonstrating that the analgesic efficacy can only be attributed to the two metabolites N-methyl- and -4-amino-antipyrine.
在摄入薄膜包衣的安乃近（诺瓦经）片和安乃近（诺瓦经）溶液后，测定了安乃近（N-甲基-、N-乙酰-和4-氨基安替比林）代谢物的唾液水平。在服用安乃近片后，对牙髓进行刺激，监测皮质诱发电位、疼痛评分和感觉阈值。在不同组的受试者中，唾液中代谢物浓度具有显著程度的可重复性。服药后20分钟，与片剂相比，溶液的吸收更快。代谢物水平与同时记录的疼痛反应相关，表明镇痛效果仅归因于两种代谢物N-甲基-和-4-氨基-安替比林。
