Do Jun Young, Kim A Young, Kang Seok Hui
Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, South Korea.
Front Nutr. 2021 Sep 24;8:742081. doi: 10.3389/fnut.2021.742081. eCollection 2021.
There is limited data on the association between phase angle (PhA) and sarcopenia using both muscle strength and muscle mass in patients undergoing peritoneal dialysis (PD). We aimed to evaluate the association between PhA and sarcopenia in patients undergoing PD. We enrolled prevalent patients undergoing PD ( = 200). The patients were divided into tertiles based on their PhA level: low ( = 66; 1.9-4°), middle ( = 68; 4.1-4.9°), and high tertiles ( = 66; 5-8°). PhA was measured by a bioimpedance analysis. Handgrip strength (HGS) was measured in all the patients. Body compositions were measured by dual energy x-ray absorptiometry (DXA). Handgrip strength (HGS) and/or lean mass indices showed poorer trends in the low tertile than in the other tertiles. PhA was positively associated with HGS and/or muscle mass index. Multivariate analyses showed that the patients in the low tertile had an odds ratio of 9.8 ( = 0.001) and 52.79 ( < 0.001) for developing sarcopenia compared with those in the middle and high tertiles, respectively. Subgroup analyses using these variables yielded results similar to those from the total cohort. This study demonstrated that PhA is independently associated with muscle mass, strength, and sarcopenia in patients undergoing PD. This result suggests that PhA can be used as a valuable and simple predictor for identifying patients undergoing PD who are at risk of sarcopenia.
关于在接受腹膜透析（PD）的患者中使用肌肉力量和肌肉质量来研究相角（PhA）与肌肉减少症之间关联的数据有限。我们旨在评估接受PD治疗的患者中PhA与肌肉减少症之间的关联。我们纳入了200例接受PD治疗的现患患者。根据患者的PhA水平将其分为三个三分位数组：低三分位数组（n = 66；1.9 - 4°）、中三分位数组（n = 68；4.1 - 4.9°）和高三分位数组（n = 66；5 - 8°）。通过生物电阻抗分析测量PhA。对所有患者测量握力（HGS）。通过双能X线吸收法（DXA）测量身体成分。与其他三分位数组相比，低三分位数组的握力（HGS）和/或瘦体重指数呈现出更差的趋势。PhA与HGS和/或肌肉质量指数呈正相关。多因素分析显示，与中三分位数组和高三分位数组相比，低三分位数组患者发生肌肉减少症的比值比分别为9.8（P = 0.001）和52.79（P < 0.001）。使用这些变量进行的亚组分析得出的结果与整个队列的结果相似。本研究表明，PhA与接受PD治疗的患者的肌肉质量、力量和肌肉减少症独立相关。这一结果表明，PhA可作为一种有价值且简单的预测指标，用于识别有肌肉减少症风险的接受PD治疗的患者。
