Chung A, Kudlick E M, Gregory J E, Royal G C, Reindorf C A
Am J Orthod Dentofacial Orthop. 1986 Sep;90(3):181-6. doi: 10.1016/0889-5406(86)90063-6.
A study was made to determine the extent of bacteremia experienced by patients undergoing orthodontic treatment with fixed appliances during periods of routine oral hygiene--namely, brushing the teeth. Sixteen orthodontic patients made up the population--11 who practiced good oral hygiene and five who demonstrated poor oral hygiene. Blood was drawn aseptically from the median cubital vein of the subjects before and 15 minutes after brushing the teeth. An aliquot of each blood specimen was added to separate blood culture bottles and incubated at 37 degrees C for a period of up to 5 days. Blood was also used to determine the immune status of the subjects. Anaerobic bacteria were recovered from the blood of nine of the 16 patients studied; aerobic bacteria were not recovered. A negative blood culture before brushing and positive blood culture after brushing were expected but did not occur. Some subjects showed bacteremia before brushing and a negative blood culture after brushing. Others showed bacteremia before and after brushing. The unexpected results could be attributed to the patients eating and/or brushing before starting the test. The study showed the capacity of specific anaerobic bacteria to remain in the bloodstream for a 15-minute period. It also demonstrated a presence of bacteria in the bloodstream before the test began.
一项研究旨在确定在进行常规口腔卫生护理（即刷牙）期间，使用固定矫治器的正畸治疗患者发生菌血症的程度。研究人群由16名正畸患者组成，其中11名口腔卫生良好，5名口腔卫生较差。在刷牙前和刷牙后15分钟，从受试者的肘正中静脉无菌采集血液。将每份血液标本的一部分添加到单独的血培养瓶中，并在37摄氏度下培养长达5天。血液还用于确定受试者的免疫状态。在研究的16名患者中，有9名患者的血液中培养出厌氧菌；未培养出需氧菌。预计刷牙前血培养阴性而刷牙后血培养阳性，但实际并未出现这种情况。一些受试者在刷牙前出现菌血症，刷牙后血培养阴性。另一些受试者在刷牙前后均出现菌血症。这些意外结果可能归因于患者在开始测试前进食和/或刷牙。该研究表明特定厌氧菌能够在血液中留存15分钟。它还证明在测试开始前血液中就存在细菌。
