岩藻多糖包被的纳米级金属有机框架用于结直肠癌放化疗时联合递送替莫唑胺和他拉唑帕尼的临床前数据
Preclinical data on co-delivery of temozolomide and talazoparib by fucodain-coated nanoscale metal organic frameworks for colorectal cancer chemoradiation.
作者信息
DuRoss Allison N, Landry Madeleine R, Thomas Charles R, Neufeld Megan J, Sun Conroy
机构信息
Department of Pharmaceutical Sciences, Oregon State University, 2730 SW Moody Ave, Portland, OR 97201, USA.
Department of Radiation Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR 97239, USA.
出版信息
Data Brief. 2021 Sep 22;38:107394. doi: 10.1016/j.dib.2021.107394. eCollection 2021 Oct.
Nanoparticle characterization and data on the effects of combined PARP inhibition and DNA damage by chemoradiation are shown. This data accompanies the research article "" (DuRoss et al., 2021) Additional characterization of the physiochemical properties of nanoscale metal organic frameworks (nMOFs) comprised of hafnium and 1,4-dicarboxybenzene (Hf-BDC) loaded with temozolomide (TMZ) and talazoparib (Tal) are presented. Toxicity data of the drug-loaded nMOF coated with fucoidan (TT@Hf-BDC-Fuco) in colorectal cancer cells, CT-26, from alamarBlue-based chemoradiation experiments are shown. Experimental methods for the nanoparticle characterization and cell-based assays of the nMOF formulation are presented.
展示了纳米颗粒表征以及关于联合PARP抑制和放化疗所致DNA损伤影响的数据。这些数据附于研究文章“”（DuRoss等人，2021年）之后。还介绍了由铪和1,4 - 二羧基苯（Hf - BDC）组成、负载替莫唑胺（TMZ）和他拉唑帕尼（Tal）的纳米级金属有机框架（nMOF）的物理化学性质的额外表征。展示了基于alamarBlue的放化疗实验中，用岩藻依聚糖包被的载药nMOF（TT@Hf - BDC - Fuco）在结肠癌细胞CT - 26中的毒性数据。介绍了纳米颗粒表征和nMOF制剂细胞检测的实验方法。
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