用于癌症治疗的联合光动力和放射治疗的纳米级金属有机骨架。
Nanoscale metal-organic frameworks for combined photodynamic & radiation therapy in cancer treatment.
机构信息
Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu, 215123, China.
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidad, Taipa, Macau, China.
出版信息
Biomaterials. 2016 Aug;97:1-9. doi: 10.1016/j.biomaterials.2016.04.034. Epub 2016 Apr 26.
Nanoscale metal organic frameworks (NMOFs) have shown great potential in biomedicine owing to their structural/chemical diversities, high molecular loading capacities, and intrinsic biodegradability. Herein, we report the rational design of a NMOF composed by hafnium (Hf(4+)) and tetrakis (4-carboxyphenyl) porphyrin (TCPP). In such Hf-TCPP NMOFs, while TCPP is a photosensitizer to allow photodynamic therapy (PDT), Hf(4+) with strong X-ray attenuation ability could serve as a radio-sensitizer to enhance radiotherapy (RT). Those NMOFs with polyethylene glycol (PEG) coating show efficient tumor homing upon intravenous injection, and thus could be used for in vivo combined RT & PDT, achieving a remarkable anti-tumor effect. Importantly, Hf-TCPP NMOFs show efficient clearance from the mouse body, minimizing concerns regarding their possible long-term toxicity. Our work thus presents a new concept of developing multifunctional NMOFs as a biodegradable carrier-free system, in which both metal ions and organic ligands are fully utilized to exert their therapeutic functions.
纳米级金属有机骨架（NMOFs）因其结构/化学多样性、高分子负载能力和固有生物降解性，在生物医药领域显示出巨大的潜力。在此，我们报告了一种由铪（Hf(4+)）和四（4-羧基苯基）卟啉（TCPP）组成的 NMOF 的合理设计。在这种 Hf-TCPP NMOFs 中，TCPP 是一种光敏剂，可用于光动力疗法（PDT），而具有强 X 射线衰减能力的 Hf(4+) 可以作为放射增敏剂，增强放射治疗（RT）。那些具有聚乙二醇（PEG）涂层的 NMOFs 在静脉注射后具有高效的肿瘤归巢作用，因此可用于体内联合 RT 和 PDT，实现显著的抗肿瘤效果。重要的是，Hf-TCPP NMOFs 能从小鼠体内有效清除，最大限度地减少了对其可能的长期毒性的担忧。我们的工作因此提出了一种新概念，即开发多功能 NMOFs 作为一种可生物降解的无载体系统，其中金属离子和有机配体都被充分利用来发挥其治疗功能。
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