Lurie Children's Hospital of Chicago, 225 E Chicago, Chicago, IL, 60611, USA.
Northwestern University Feinberg School of Medicine, 420 E Superior St, Chicago, IL, 60611, USA.
Cardiovasc Intervent Radiol. 2022 Feb;45(2):190-196. doi: 10.1007/s00270-021-02945-8. Epub 2021 Oct 10.
Unicameral bone cysts (UBCs) are benign lesions that primarily occur in childhood and can present with pain, pathologic fracture and growth disturbances. Existing treatment approaches for the management of UBCs are highly variable and recurrence is not uncommon. This study seeks to evaluate near-term outcomes of an image-guided, minimally invasive combination of chemical sclerotherapy and synthetic grafting as a novel outpatient management treatment option for UBCs.
Retrospective evaluation from August 2018 to July 2020 of fourteen pediatric patients, ages 5-14 years, undergoing treatment for a UBC, at a single institution. All UBCs were treated in a single, minimally invasive, image-guided procedure using percutaneous needle access into the UBC followed by chemical sclerotherapy and injection of regenerative synthetic graft. Patients were followed clinically and with serial radiographs to evaluate for healing and complications, with an average follow-up of 13.7 months. Descriptive statistics were performed.
Twelve of 14 (85.7%) patients showed Modified Neer classification class 1 or 2 healed cysts at their most recent follow-up. There were two recurrences. All patients were pain-free and returned to normal physical activity on average within 2.0 months, and all patients with healed cysts remained asymptomatic at the most recent follow-up. There were no complications related to the procedures.
Image-guided chemical sclerosis and bone grafting is a minimally invasive treatment option for unicameral bone cysts and compares favorably to other existing treatment options. The preliminary findings of this technique are promising as an alternative management option for UBCs.
单房性骨囊肿（UBC）是一种主要发生在儿童期的良性病变，可表现为疼痛、病理性骨折和生长障碍。现有的 UBC 管理治疗方法差异很大，复发并不少见。本研究旨在评估一种新的门诊管理治疗选择，即图像引导下微创化学硬化和合成移植物联合治疗 UBC 的近期结果。
对 2018 年 8 月至 2020 年 7 月在一家机构接受 UBC 治疗的 14 名 5-14 岁儿童患者进行回顾性评估。所有 UBC 均采用经皮穿刺针进入 UBC 进行单一微创、图像引导的手术进行治疗，然后进行化学硬化和再生合成移植物注射。通过临床和连续影像学评估愈合和并发症对患者进行随访，平均随访 13.7 个月。进行描述性统计分析。
14 例患者中有 12 例（85.7%）在最近的随访中显示改良 Neer 分类 1 或 2 级愈合囊肿。有 2 例复发。所有患者均无疼痛，平均在 2.0 个月内恢复正常体力活动，所有愈合囊肿的患者在最近的随访中均无症状。无与手术相关的并发症。
图像引导下的化学硬化和植骨是治疗单房性骨囊肿的一种微创治疗选择，与其他现有治疗方法相比具有优势。该技术的初步发现作为 UBC 的替代治疗选择具有很大的潜力。
