Modugno Rocco Luigi, Testi Ilaria, Pavesio Carlos
Department of Neuroscience, Ophthalmology Unit, University of Padua, Padua, Italy.
Moorfields Eye Hospital, National Health Service Foundation Trust, 162 City Rd, Old Street, London, EC1V 2PD, UK.
J Ophthalmic Inflamm Infect. 2021 Oct 10;11(1):37. doi: 10.1186/s12348-021-00267-x.
Systemic corticosteroids and immunosuppressant agents are the mainstay of therapy for non-infectious uveitis (NIU). However, the risks associated with systemic administration and the need of delivering an effective and safe anti-inflammatory treatment targeted to the site of inflammation have prompt the use of local therapy in the management of NIU. This review will analyse the different local treatment options available, including corticosteroids, anti-vascular endothelial growth factor (VEGF), methotrexate and the recent biologics.
全身用皮质类固醇和免疫抑制剂是治疗非感染性葡萄膜炎（NIU）的主要手段。然而，全身给药相关的风险以及需要针对炎症部位提供有效且安全的抗炎治疗，促使人们在NIU的治疗中采用局部治疗。本综述将分析现有的不同局部治疗选择，包括皮质类固醇、抗血管内皮生长因子（VEGF）、甲氨蝶呤以及最近的生物制剂。
