特比萘芬与伊曲康唑联合抗 种分离株的抗真菌作用。
Antifungal Combination of Terbinafine with Itraconazole against Isolates of Species.
机构信息
Unité de Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, AP-HP, Faculté de Médecine, Université de Paris, Paris, France.
Department of Internal Medicine, Respiratory and Critical Care Medicine, University Hospital Marburg, Marburg, Germany.
出版信息
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0144921. doi: 10.1128/AAC.01449-21. Epub 2021 Oct 11.
Abstract
Terbinafine is used as the first-line therapy for dermatophytosis, but the incidence of terbinafine resistance is increasing. A combination of terbinafine with itraconazole was tested using the checkerboard method based on the EUCAST methodology for antifungal susceptibility testing against 9 terbinafine-susceptible and 7 terbinafine-resistant clinical isolates of spp. from India. Synergistic interactions were observed for 4/9 of the susceptible isolates, with fractional inhibitory concentration index (FICI) values of 0.3125 to 0.5, and for 4/7 of the resistant isolates, with FICI values of 0.032 to 0.3125.
摘要
特比萘芬被用作治疗皮肤癣菌病的一线药物，但特比萘芬耐药的发生率正在增加。根据 EUCAST 抗真菌药敏检测方法，采用棋盘微量稀释法，对来自印度的 9 株特比萘芬敏感和 7 株特比萘芬耐药的临床分离株进行了特比萘芬与伊曲康唑联合用药的测试。在 9 株敏感株中有 4 株观察到协同作用，其部分抑菌浓度指数（FICI）值为 0.3125 至 0.5，在 7 株耐药株中有 4 株观察到协同作用，FICI 值为 0.032 至 0.3125。
相似文献
1
Antifungal Combination of Terbinafine with Itraconazole against Isolates of Species.特比萘芬与伊曲康唑联合抗 种分离株的抗真菌作用。
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0144921. doi: 10.1128/AAC.01449-21. Epub 2021 Oct 11.
2
In vitro susceptibility testing of ciclopirox, terbinafine, ketoconazole and itraconazole against dermatophytes and nondermatophytes, and in vitro evaluation of combination antifungal activity.环吡酮、特比萘芬、酮康唑和伊曲康唑对皮肤癣菌和非皮肤癣菌的体外药敏试验以及联合抗真菌活性的体外评估。
Br J Dermatol. 2003 Aug;149(2):296-305. doi: 10.1046/j.1365-2133.2003.05418.x.
3
Terbinafine-Resistant Dermatophytes and the Presence of Trichophyton indotineae in North America.北美地区特比萘芬耐药的皮肤癣菌和堇毛癣菌的存在。
J Clin Microbiol. 2023 Aug 23;61(8):e0056223. doi: 10.1128/jcm.00562-23. Epub 2023 Jul 11.
4
Evaluation of Gradient Concentration Strips for Detection of Terbinafine Resistance in spp.评估梯度浓度条在检测 spp. 中特比萘芬耐药性中的应用
Antimicrob Agents Chemother. 2023 Jun 15;67(6):e0171622. doi: 10.1128/aac.01716-22. Epub 2023 May 10.
5
Detection of terbinafine-resistant Trichophyton indotineae isolates within the Trichophyton mentagrophytes species complex isolated from patients in Hue City, Vietnam: A comprehensive analysis.越南顺化市从患者中分离出的特比萘芬耐药须癣毛癣菌种复合体中的 Trichophyton indotineae 分离株的检测：综合分析。
Med Mycol. 2024 Aug 2;62(8). doi: 10.1093/mmy/myae088.
6
Antifungal drug susceptibility profile of clinically important dermatophytes and determination of point mutations in terbinafine-resistant isolates.临床重要皮肤癣菌的抗真菌药物敏感性分析及特比萘芬耐药分离株点突变的检测。
Eur J Clin Microbiol Infect Dis. 2018 Oct;37(10):1841-1846. doi: 10.1007/s10096-018-3317-4. Epub 2018 Jul 7.
7
8
In vitro Azole Susceptibility Testing of Japanese Isolates of Itraconazole-Resistant Dermatophytes.体外唑类药物敏感性试验对伊曲康唑耐药皮肤癣菌的日本分离株。
Med Mycol J. 2023;64(4):103-105. doi: 10.3314/mmj.23-00005.
9
In vitro susceptibility of dermatomycoses agents to six antifungal drugs and evaluation by fractional inhibitory concentration index of combined effects of amorolfine and itraconazole in dermatophytes.皮肤癣菌制剂对六种抗真菌药物的体外敏感性以及阿莫罗芬和伊曲康唑对皮肤癣菌联合作用的分数抑菌浓度指数评估
Microbiol Immunol. 2014 Jan;58(1):1-8. doi: 10.1111/1348-0421.12109.
10
Combinatorial effect of fluconazole, itraconazole, and terbinafine with different culture extracts of Candida parapsilosis and Trichophyton spp. against Trichophyton rubrum.氟康唑、伊曲康唑和特比萘芬联合不同近平滑念珠菌和须癣毛癣菌培养提取物对红色毛癣菌的协同作用。
Int Microbiol. 2024 Jun;27(3):899-905. doi: 10.1007/s10123-023-00438-x. Epub 2023 Oct 24.
引用本文的文献
1
Galactose Inhibits the Translation of Erg1 that Enhances the Antifungal Activities of Azoles Against .半乳糖抑制Erg1的翻译，Erg1可增强唑类药物对……的抗真菌活性。
Antibiotics (Basel). 2025 Aug 5;14(8):799. doi: 10.3390/antibiotics14080799.
2
Essential Oil as a Promising Antimicrobial Agent Against Cutaneous Pathogens: Mechanistic Insights into Its Anti- Activity.精油作为一种有前景的抗皮肤病原菌抗菌剂：对其抗菌活性的作用机制洞察
Microorganisms. 2025 May 28;13(6):1241. doi: 10.3390/microorganisms13061241.
3
Antifungal effects of andrographolide and its combination with amphotericin B against selected fungal pathogens.穿心莲内酯及其与两性霉素B联合使用对特定真菌病原体的抗真菌作用。
PeerJ. 2025 Jun 16;13:e19544. doi: 10.7717/peerj.19544. eCollection 2025.
4
The mechanism research of itraconazole combined with aspirin in the treatment of vulvovaginal candidiasis through NF-κB signaling pathway.伊曲康唑联合阿司匹林通过NF-κB信号通路治疗外阴阴道念珠菌病的机制研究
Biomol Biomed. 2025 Apr 26;25(6):1302-1313. doi: 10.17305/bb.2024.11358.
5
Causes Cutaneous and Extracutaneous Feline Dermatophytic Pseudomycetomas: Molecular Identification and Clinicopathological Characteristics.猫皮肤和皮肤外皮肤癣菌假真菌瘤的病因：分子鉴定及临床病理特征
J Fungi (Basel). 2024 Aug 14;10(8):576. doi: 10.3390/jof10080576.
6
Invasive fungal infections and oomycoses in cats 2. Antifungal therapy.猫侵袭性真菌感染和真菌病 2. 抗真菌治疗。
J Feline Med Surg. 2024 Jan;26(1):1098612X231220047. doi: 10.1177/1098612X231220047.
7
Efficacy of Terbinafine and Itraconazole Combination Therapy Versus Terbinafine or Itraconazole Monotherapy in the Management of Fungal Diseases: A Systematic Review and Meta-Analysis.特比萘芬与伊曲康唑联合治疗对比特比萘芬或伊曲康唑单药治疗在真菌病管理中的疗效：一项系统评价与荟萃分析
Cureus. 2023 Nov 14;15(11):e48819. doi: 10.7759/cureus.48819. eCollection 2023 Nov.
8
Management of Dermatophytosis: Real-World Indian Perspective.皮肤癣菌病的管理：印度的实际情况
Indian Dermatol Online J. 2023 Apr 27;14(3):347-356. doi: 10.4103/idoj.idoj_643_22. eCollection 2023 May-Jun.
9
The emergence and worldwide spread of the species Trichophyton indotineae causing difficult-to-treat dermatophytosis: A new challenge in the management of dermatophytosis.引起难以治疗的皮肤癣菌病的印多蒂毛癣菌的出现及全球传播：皮肤癣菌病管理中的新挑战。
PLoS Pathog. 2022 Sep 29;18(9):e1010795. doi: 10.1371/journal.ppat.1010795. eCollection 2022 Sep.
10
In Vitro Study of the Interaction of Gentamicin with Ceftriaxone and Azithromycin against Using Agar Dilution Method.庆大霉素与头孢曲松和阿奇霉素相互作用的体外研究：采用琼脂稀释法对抗…… （原文中“against”后内容缺失）
Antibiotics (Basel). 2022 Aug 10;11(8):1083. doi: 10.3390/antibiotics11081083.
本文引用的文献
1
Taxonomy of the Trichophyton mentagrophytes/T. interdigitale Species Complex Harboring the Highly Virulent, Multiresistant Genotype T. indotineae.地霉属毛癣菌/须癣毛癣菌复合种中携带高度致病、多耐药基因型 T. indotineae 的分类学研究。
Mycopathologia. 2021 Jun;186(3):315-326. doi: 10.1007/s11046-021-00544-2. Epub 2021 Apr 13.
2
In Vitro Combination Effect of Topical and Oral Anti-Onychomycosis Drugs on and .外用和口服抗甲真菌病药物对……的体外联合效应 以及…… （原文表述不完整，翻译可能存在一定局限性）
J Fungi (Basel). 2021 Mar 12;7(3):208. doi: 10.3390/jof7030208.
3
Emerging antifungal treatment failure of dermatophytosis in Europe: take care or it may become endemic.欧洲皮肤癣菌病新出现的抗真菌治疗失败：需加以关注，否则可能会成为地方病。
J Eur Acad Dermatol Venereol. 2021 Jul;35(7):1582-1586. doi: 10.1111/jdv.17241. Epub 2021 Apr 22.
4
Terbinafine Hydrochloride Combined With Itraconazole for Fungal Skin Diseases: A Randomized Controlled Trial.盐酸特比萘芬联合伊曲康唑治疗皮肤真菌病：一项随机对照试验。
Am J Ther. 2021;28(2):e179-e186. doi: 10.1097/MJT.0000000000001075.
5
Techniques for the Assessment of In Vitro and In Vivo Antifungal Combinations.体外和体内抗真菌联合用药评估技术
J Fungi (Basel). 2021 Feb 4;7(2):113. doi: 10.3390/jof7020113.
6
How to: perform antifungal susceptibility testing of microconidia-forming dermatophytes following the new reference EUCAST method E.Def 11.0, exemplified by Trichophyton.方法：采用新的欧盟药敏试验委员会（EUCAST）参考方法 E.Def 11.0 对微菌核形成的皮肤癣菌进行抗真菌药敏试验，以毛癣菌为例。
Clin Microbiol Infect. 2021 Jan;27(1):55-60. doi: 10.1016/j.cmi.2020.08.042. Epub 2020 Sep 8.
7
In vitro antidermatophytic synergism of double and triple combination of clioquinol with ciclopirox and terbinafine.体外氯碘羟喹与环吡酮胺和特比萘芬的双重和三重组合的抗皮肤真菌协同作用。
Mycoses. 2020 Sep;63(9):993-1001. doi: 10.1111/myc.13127. Epub 2020 Jul 1.
8
Trichophyton indotineae sp. nov.: A New Highly Terbinafine-Resistant Anthropophilic Dermatophyte Species.新发高度特比萘芬耐药亲人性皮肤癣菌物种：枝孢霉 indotineae 种。
Mycopathologia. 2020 Dec;185(6):947-958. doi: 10.1007/s11046-020-00455-8. Epub 2020 May 24.
9
Alarming India-wide phenomenon of antifungal resistance in dermatophytes: A multicentre study.令人震惊的印度范围内的皮肤真菌抗药性现象：一项多中心研究。
Mycoses. 2020 Jul;63(7):717-728. doi: 10.1111/myc.13091. Epub 2020 May 4.
10
Voriconazole plus terbinafine combination antifungal therapy for invasive Lomentospora prolificans infections: analysis of 41 patients from the FungiScope® registry 2008-2019.伏立康唑联合特比萘芬联合抗真菌治疗侵袭性繁茂枝孢菌感染：2008-2019 年 FungiScope®登记处 41 例患者分析。
Clin Microbiol Infect. 2020 Jun;26(6):784.e1-784.e5. doi: 10.1016/j.cmi.2020.01.012. Epub 2020 Jan 20.
Zotero 插件