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Mycopathologia. 2021 Jun;186(3):315-326. doi: 10.1007/s11046-021-00544-2. Epub 2021 Apr 13.
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特比萘芬与伊曲康唑联合抗 种分离株的抗真菌作用。

Antifungal Combination of Terbinafine with Itraconazole against Isolates of Species.

机构信息

Unité de Parasitologie-Mycologie, Hôpital Européen Georges Pompidou, AP-HP, Faculté de Médecine, Université de Paris, Paris, France.

Department of Internal Medicine, Respiratory and Critical Care Medicine, University Hospital Marburg, Marburg, Germany.

出版信息

Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0144921. doi: 10.1128/AAC.01449-21. Epub 2021 Oct 11.

DOI:10.1128/AAC.01449-21
PMID:34633845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8765265/
Abstract

Terbinafine is used as the first-line therapy for dermatophytosis, but the incidence of terbinafine resistance is increasing. A combination of terbinafine with itraconazole was tested using the checkerboard method based on the EUCAST methodology for antifungal susceptibility testing against 9 terbinafine-susceptible and 7 terbinafine-resistant clinical isolates of spp. from India. Synergistic interactions were observed for 4/9 of the susceptible isolates, with fractional inhibitory concentration index (FICI) values of 0.3125 to 0.5, and for 4/7 of the resistant isolates, with FICI values of 0.032 to 0.3125.

摘要

特比萘芬被用作治疗皮肤癣菌病的一线药物，但特比萘芬耐药的发生率正在增加。根据 EUCAST 抗真菌药敏检测方法，采用棋盘微量稀释法，对来自印度的 9 株特比萘芬敏感和 7 株特比萘芬耐药的临床分离株进行了特比萘芬与伊曲康唑联合用药的测试。在 9 株敏感株中有 4 株观察到协同作用，其部分抑菌浓度指数（FICI）值为 0.3125 至 0.5，在 7 株耐药株中有 4 株观察到协同作用，FICI 值为 0.032 至 0.3125。