Harth H, Pees H, Zankl H
Cancer Genet Cytogenet. 1986 Oct;23(2):127-33.
A case of acute myelomonocytic leukemia is reported which was hematologically classified as M4 (FAB), because the patient had a high count of immature eosinophils with typical histochemical features in the bone marrow. An abnormal chromosome #16 was found besides a trisomy 22 or a monosomy 18 in part of the cultured bone marrow cells and unstimulated blood cells but not in directly prepared bone marrow. The structural aberration of chromosomes #16, which was demonstrated best by CBG-banding, was more likely due to a partial deletion of the long arm than to an inversion. The difficulties involved in correct cytogenetic diagnosis of such cases are discussed.
报告了一例急性粒单核细胞白血病病例，血液学分类为M4（FAB）型，因为患者骨髓中未成熟嗜酸性粒细胞计数较高且具有典型的组织化学特征。除了部分培养的骨髓细胞和未刺激的血细胞中存在22号染色体三体或18号染色体单体外，直接制备的骨髓中未发现异常，同时发现了16号染色体异常。16号染色体的结构畸变通过CBG显带法显示得最为清晰，更可能是由于长臂部分缺失而非倒位。文中讨论了对此类病例进行正确细胞遗传学诊断所涉及的困难。
