Abbondanzo S L, Gray R G, Whang-Peng J, Jacobson R J
Arch Pathol Lab Med. 1987 Apr;111(4):330-2.
A patient presented with a myelodysplastic syndrome and bone marrow eosinophilia that evolved six months later into an acute nonlymphocytic leukemia (ANLL). Cytogenetic analyses of the bone marrow revealed 86% of the metaphases with 45,X-Y,inv(16)(p13;q22),t(11;17) (q11;q25),del(21)(q13) and 14% of the metaphases with the same abnormalities but with a Y chromosome. The association of ANLL, bone marrow eosinophilia, and abnormal chromosome 16 has previously been reported and has been suggested to have a favorable prognosis. Our patient is unique in that ANLL was preceded by a preleukemic phase associated with bone marrow eosinophilia. When complete remission was achieved, the bone marrow cytogenetics returned to normal, and the eosinophilia disappeared.
一名患者最初表现为骨髓增生异常综合征和骨髓嗜酸性粒细胞增多，6个月后进展为急性非淋巴细胞白血病（ANLL）。对其骨髓进行的细胞遗传学分析显示，86%的中期细胞具有45,X-Y,inv(16)(p13;q22),t(11;17)(q11;q25),del(21)(q13)，14%的中期细胞具有相同异常但有Y染色体。ANLL、骨髓嗜酸性粒细胞增多和16号染色体异常的关联此前已有报道，且提示预后良好。我们的患者具有独特性，即ANLL之前存在与骨髓嗜酸性粒细胞增多相关的白血病前期。当实现完全缓解时，骨髓细胞遗传学恢复正常，嗜酸性粒细胞增多消失。
