Universität der Bundeswehr München, Institut für Angewandte Physik und Messtechnik (LRT2), Neubiberg, Bavaria, Germany.
ENEA, Frascati, Rome, Italy.
PLoS One. 2021 Oct 11;16(10):e0258477. doi: 10.1371/journal.pone.0258477. eCollection 2021.
To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W.
为了展示质子微束放射治疗(pMBRT)作为一种治疗肿瘤疾病的新方法的巨大潜力,设计了一种临床前质子微束放射设施。它基于串联的范德格拉夫加速器,提供 16 MeV 的质子束和 3 GHz 的直线加速器后加速器(设计:AVO-ADAM S.A,日内瓦,瑞士和 ENEA,弗拉斯卡蒂,意大利)。为了将串联束的传输通过后加速器增强 3 倍,设计并制造了两个漂移管聚束器单元:一个钎焊的 5 间隙结构(TOP-IMPLART 项目(ENEA)的自适应 SCDTL 罐)和一个非钎焊的低预算 4 间隙结构。两者均由铜制成。使用 16 MeV 串联加速器束和 Q3D 磁谱仪评估了这两个不同制造单元的性能。两个聚束器单元都实现了所需的 42 kV 总和电压幅度和功率馈送小于 800 W 时的幅度稳定性。