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两个 3GHz 聚束单元的概念和性能评估,以优化新型临床前质子微束辐照装置的剂量率。

Concept and performance evaluation of two 3 GHz buncher units optimizing the dose rate of a novel preclinical proton minibeam irradiation facility.

机构信息

Universität der Bundeswehr München, Institut für Angewandte Physik und Messtechnik (LRT2), Neubiberg, Bavaria, Germany.

ENEA, Frascati, Rome, Italy.

出版信息

PLoS One. 2021 Oct 11;16(10):e0258477. doi: 10.1371/journal.pone.0258477. eCollection 2021.

Abstract

To demonstrate the large potential of proton minibeam radiotherapy (pMBRT) as a new method to treat tumor diseases, a preclinical proton minibeam radiation facility was designed. It is based on a tandem Van-de-Graaff accelerator providing a 16 MeV proton beam and a 3 GHz linac post-accelerator (designs: AVO-ADAM S.A, Geneva, Switzerland and ENEA, Frascati, Italy). To enhance the transmission of the tandem beam through the post-accelerator by a factor of 3, two drift tube buncher units were designed and constructed: A brazed 5-gap structure (adapted SCDTL tank of the TOP-IMPLART project (ENEA)) and a non-brazed low budget 4-gap structure. Both are made of copper. The performance of the two differently manufactured units was evaluated using a 16 MeV tandem accelerator beam and a Q3D magnetic spectrograph. Both buncher units achieve the required summed voltage amplitude of 42 kV and amplitude stability at a power feed of less than 800 W.

摘要

为了展示质子微束放射治疗(pMBRT)作为一种治疗肿瘤疾病的新方法的巨大潜力,设计了一种临床前质子微束放射设施。它基于串联的范德格拉夫加速器,提供 16 MeV 的质子束和 3 GHz 的直线加速器后加速器(设计:AVO-ADAM S.A,日内瓦,瑞士和 ENEA,弗拉斯卡蒂,意大利)。为了将串联束的传输通过后加速器增强 3 倍,设计并制造了两个漂移管聚束器单元:一个钎焊的 5 间隙结构(TOP-IMPLART 项目(ENEA)的自适应 SCDTL 罐)和一个非钎焊的低预算 4 间隙结构。两者均由铜制成。使用 16 MeV 串联加速器束和 Q3D 磁谱仪评估了这两个不同制造单元的性能。两个聚束器单元都实现了所需的 42 kV 总和电压幅度和功率馈送小于 800 W 时的幅度稳定性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8f09/8504737/48fee9b9ae5d/pone.0258477.g001.jpg

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