Department of Internal Medicine, Jeonbuk National University Medical School, Jeonju, Republic of Korea.
Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonju, Republic of Korea.
Am J Trop Med Hyg. 2021 Oct 11;105(6):1680-1683. doi: 10.4269/ajtmh.20-1369.
Scrub typhus is an acute febrile disease caused by Orientia tsutsugamushi, which is transmitted through chigger mites. Delayed treatment results in various complications and, in severe cases, death. Granzymes are secreted by cytotoxic T lymphocytes or natural killer cells and are known to play an important role in controlling intracellular pathogens. To date, few studies have been done on granzymes in patients with scrub typhus. In this study, granzymes A and B showed a significant increase during the acute stage of scrub typhus compared with healthy control subjects, and decreased sharply after treatment. In addition, granzymes A and B were significantly high in the moderately elevated liver enzyme group. In conclusion, it appears that the host during the acute phase of scrub typhus increases cytotoxic T-cell activity to control infection.
恙虫病是由恙虫东方体引起的急性发热性疾病，通过恙螨幼虫传播。延迟治疗会导致各种并发症，严重情况下会导致死亡。颗粒酶由细胞毒性 T 淋巴细胞或自然杀伤细胞分泌，已知在控制细胞内病原体方面发挥重要作用。迄今为止，对恙虫病患者的颗粒酶研究较少。在这项研究中，与健康对照组相比，恙虫病急性期的颗粒酶 A 和 B 明显增加，治疗后急剧下降。此外，中度升高的肝酶组中的颗粒酶 A 和 B 明显升高。总之，恙虫病急性期的宿主似乎会增加细胞毒性 T 细胞的活性来控制感染。
