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更年期不仅仅是热潮红:顺势疗法研究中缺失了什么?一篇叙述性综述。

Menopause is more than Hot Flashes: What is Missing in Homeopathic Research? A Narrative Review.

机构信息

Homeopathy Outpatient Service, Hospital Juárez de México, Mexico City, Mexico.

出版信息

Homeopathy. 2022 May;111(2):79-96. doi: 10.1055/s-0041-1733971. Epub 2021 Oct 11.

Abstract

BACKGROUND

Menopausal complaints are frequently treated with homeopathy in daily practice worldwide. Recently, vasomotor symptoms have been understood to have implications as predictors of other important and long-term outcomes, causing increased risk of mortality and/or disability.

METHODS

A comprehensive search of the literature was conducted to investigate whether homeopathic treatments for menopausal women with vasomotor symptoms have a positive effect on other important health outcomes associated with menopause, such as cardiovascular disease, neurocognitive impairment, metabolic and mood disorders, or osteoporosis.

RESULTS

Though observational studies have shown encouraging results in reducing the severity and frequency of hot flashes in women treated with homeopathy, few randomized controlled trials have shown positive results. In most of the studies using homeopathy, the primary outcome is reduction in the frequency and severity of hot flashes, and other menopausal complaints are assessed secondarily as a part of the symptoms evaluated in the menopausal scales. Quality of life improves with homeopathic treatments for hot flashes, but there is scarce evidence of the effect of homeopathy on other health outcomes associated with menopause. Limited evidence exists in the case of menopausal women treated with individualized homeopathy for depression and metabolic disorders.

CONCLUSION

A more comprehensive approach for treating menopause in routine homeopathic practice constitutes a valuable opportunity to increase knowledge and high-quality research in this field. Future homeopathic research for menopause should be focused on well-designed, double-blind, placebo-controlled, randomized trials as well as on pragmatic trials to show whether homeopathic treatments for vasomotor symptoms can also improve outcomes that are well-known to increase the risk of mortality and/or disability.

摘要

背景

在全球范围内,更年期症状经常采用顺势疗法进行治疗。最近,人们认识到血管舒缩症状与其他重要的长期结果有一定的关系,这些症状会增加死亡率和/或残疾的风险。

方法

为了研究治疗有血管舒缩症状的更年期女性的顺势疗法是否对与更年期相关的其他重要健康结果(如心血管疾病、神经认知障碍、代谢和情绪障碍或骨质疏松症)有积极影响,我们进行了全面的文献检索。

结果

尽管观察性研究表明,顺势疗法在减轻女性热潮红的严重程度和频率方面有令人鼓舞的结果,但很少有随机对照试验显示出积极的结果。在大多数采用顺势疗法的研究中,主要结果是减少热潮红的频率和严重程度,其他更年期症状作为更年期量表评估的一部分进行次要评估。采用顺势疗法治疗热潮红可提高生活质量,但关于顺势疗法对与更年期相关的其他健康结果的影响,证据有限。在接受个体化顺势疗法治疗抑郁和代谢紊乱的更年期女性中,证据有限。

结论

在常规顺势疗法实践中更全面地治疗更年期构成了增加该领域知识和高质量研究的宝贵机会。未来针对更年期的顺势疗法研究应侧重于设计良好、双盲、安慰剂对照、随机试验以及实用性试验,以证明治疗血管舒缩症状的顺势疗法是否也能改善已知会增加死亡率和/或残疾风险的结果。

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