Bedolla-Barajas Martín, Morales-Romero Jaime, Bedolla-Pulido Tonantzin Isis, Flores-Razo Miriam Montzerrat, Morales Marco Antonio, Rosales Gustavo, Arellano-Arteaga Kevin Javier, Paz-Velarde Beatriz Alejandra
Nuevo Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Servicio de Alergia e Inmunología Clínica, Guadalajara, Jalisco, México.
Rev Alerg Mex. 2021 Jul-Sep;68(3):152-159. doi: 10.29262/ram.v67i3.893.
To determine the prevalence of blood eosinophilia in adults with chronic obstructive pulmonary disease (COPD) according to different cut-off points.
A cross-sectional study was carried out in patients with COPD. The frequency of blood eosinophilia was determined by absolute (cells/ µL) and relative (%) eosinophil count. Multivariate methods were used in order to identify the associated factors.
81 patients were included; the mean age was 71.9 ± 9.8 years; 46 (57%) of the patients were men. The prevalence of eosinophilia for the cut-off points of ≥ 100, ≥ 150, ≥ 200, ≥ 300, and ≥ 400 cells/µL was of 64.2%, 37.0%, 16.1%, and 9.9% respectively. Out of 81 patients, 34 (42%) had a relative eosinophil concentration of ≥ 2%; 21 (25.9%) ≥ 3%; 14 patients (17.3%) had ≥ 4%; and 10 patients (12.3%) had ≥ 5%. Eosinophilia of ≥ 100 cells/µL was associated with age of ≥ 80 years (OR = 6.04, p = 0.026), and with the exacerbation of COPD (OR = 9.40, p = 0.038); in contrast, eosinophilia of ≥ 2% was associated only with age of ≥ 80 years (OR = 3.73, p = 0.020). In addition, the eosinophil count of ≥ 100 and < 300 cells/µL was associated with the exacerbation of COPD (OR = 11.00, p = 0.026).
Our results suggest that the frequency of eosinophilia in the context of COPD shows substantial variations according to the used definition.
根据不同的切点确定慢性阻塞性肺疾病（COPD）成人患者血液嗜酸性粒细胞增多症的患病率。
对COPD患者进行横断面研究。通过绝对（细胞/µL）和相对（%）嗜酸性粒细胞计数来确定血液嗜酸性粒细胞增多症的频率。采用多变量方法来识别相关因素。
纳入81例患者；平均年龄为71.9±9.8岁；46例（57%）患者为男性。嗜酸性粒细胞增多症在≥100、≥150、≥200、≥300和≥400细胞/µL切点时的患病率分别为64.2%、37.0%、16.1%和9.9%。在81例患者中，34例（42%）的相对嗜酸性粒细胞浓度≥2%；21例（25.9%）≥3%；14例患者（17.3%）≥4%；10例患者（12.3%）≥5%。≥100细胞/µL的嗜酸性粒细胞增多症与≥80岁的年龄相关（OR = 6.04，p = 0.026），且与COPD急性加重相关（OR = 9.40，p = 0.038）；相比之下，≥2%的嗜酸性粒细胞增多症仅与≥80岁的年龄相关（OR = 3.73，p = 0.020）。此外，≥100且<300细胞/µL的嗜酸性粒细胞计数与COPD急性加重相关（OR = 11.00，p = 0.026）。
我们的结果表明，在COPD背景下，嗜酸性粒细胞增多症的频率根据所使用的定义显示出很大差异。
