López Catalina, Cardona Ricardo
Universidad de Antioquia, Facultad de Medicina, Grupo de Alergología Clínica y Experimental, Medellín, Colombia.
Rev Alerg Mex. 2021 Jul-Sep;68(3):214-217. doi: 10.29262/ram.v68i3.869.
In December 2019, a new coronavirus was identified as the causal agent of the 2019 coronavirus disease (COVID-19) with a wide clinical spectrum that goes from asymptomatic cases to critical and fatal cases. Its usual manifestations are fever, cough, and fatigue; although some cases present skin lesions.
The first case was a 30-year-old woman with a history of controlled solar urticaria who presented erythematous and pruritic wheals in malar and cervical regions and extremities; associated with general malaise, headaches, and nausea, in whom the presence of COVID-19 was confirmed; her condition improved with a quadruple dose of antihistamines. The second case was a 47-year-old woman with a history of wasp sting anaphylaxis, without mastocytosis, who presented nasal congestion, headaches, and hypogeusia associated with generalized, erythematous, and pruritic wheals, with confirmation of COVID-19; her condition improved with quadruple doses of antihistamines.
Cutaneous manifestations associated with COVID-19 are frequent and can be classified as inflammatory and vascular. Among them, urticarial lesions occupy the fourth place, and although there could be some predominance of these in patients with a history of allergies, more studies are required to define an association.
2019年12月，一种新型冠状病毒被确定为2019冠状病毒病（COVID-19）的病原体，其临床谱广泛，从无症状病例到重症和致命病例。其常见表现为发热、咳嗽和乏力；尽管有些病例会出现皮肤病变。
首例病例为一名30岁女性，有可控性日光性荨麻疹病史，其面颊、颈部和四肢出现红斑性和瘙痒性风团；伴有全身不适、头痛和恶心，确诊感染COVID-19； quadruple剂量的抗组胺药治疗后病情好转。第二例病例为一名47岁女性，有黄蜂蜇伤过敏史，无肥大细胞增多症，出现鼻塞、头痛和味觉减退，伴有全身性红斑性和瘙痒性风团，确诊感染COVID-19； quadruple剂量的抗组胺药治疗后病情好转。
与COVID-19相关的皮肤表现很常见，可分为炎症性和血管性。其中，荨麻疹样病变占第四位，尽管有过敏史的患者中可能有一定的优势，但仍需要更多研究来确定两者之间的关联。 （注：原文中“quadruple dose”未明确具体含义，这里保留英文表述）
