State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, People's Republic of China.
Org Biomol Chem. 2021 Oct 27;19(41):8924-8928. doi: 10.1039/d1ob01806j.
Herein we report a mild, general protocol for visible-light-mediated alkylation of 4-alkyl-1,4-dihydropyridines with alkenyl sulfones. The protocol permits efficient functionalization of sulfones with a broad range of cyclic and acyclic secondary and tertiary alkyl groups and is scalable to the gram level. Its excellent functional group tolerance and mildness make it suitable for late-stage functionalization of natural products and drug molecules.
在此，我们报告了一种温和的、通用的可见光介导的 4-烷基-1,4-二氢吡啶与烯基砜的烷基化方法。该方案允许对具有广泛范围的环状和非环状仲烷基和叔烷基的砜进行有效官能化，并且可扩展到克级规模。其出色的官能团耐受性和温和性使其适用于天然产物和药物分子的后期功能化。
