Graduate School, Niigata University of Health and Welfare, Niigata-City, Niigata, 950-3198, Japan.
Institute for Human Movement and Medical Sciences, Niigata University of Health and Welfare, Niigata-City, Niigata, Niigata, 950-3198, Japan.
Cereb Cortex. 2022 Jun 7;32(12):2635-2643. doi: 10.1093/cercor/bhab370.
Although brain gray matter (GM) plastically changes during short-term training, it is still unclear whether brain structures are stable for short periods (several months). Therefore, this study aimed to re-test the short-term variability of GM volumes and to clarify the effect of factors (gender and BDNF-genotype) expected to contribute to such variability. The subjects comprised 41 young healthy adults. T1-weighted images were acquired twice with an interval of approximately 4 months using a 3 T-MRI scanner. Voxel-based morphometry (VBM) was used to calculate GM volumes in 47 regions. The intraclass correlation coefficient (ICC) and Test-retest variability (%TRV) were used as indices of variability. As a result, the ICCs in 43 regions were excellent (ICC > 0.90) and those in 3 regions were good (ICC > 0.80), whereas the ICC in the thalamus was moderate (ICC = 0.694). Women had a higher %TRV than men in 5 regions, and %TRV of the Val66Val group was higher than that of the Met carrier group in 2 regions. Moreover, the Female-Val66Val group had a higher %TRV than the Male-Met carrier group in 3 regions. These results indicate that although the short-term variability of GM volumes is small, it is affected by within-subject factors.
虽然脑灰质（GM）在短期训练中会发生可塑性变化，但脑结构在短时间内（几个月）是否稳定仍不清楚。因此，本研究旨在重新测试 GM 体积的短期可变性，并阐明预期有助于这种可变性的因素（性别和 BDNF 基因型）的影响。研究对象包括 41 名年轻健康的成年人。使用 3T-MRI 扫描仪，两次采集 T1 加权图像，间隔约 4 个月。体素基形态计量学（VBM）用于计算 47 个区域的 GM 体积。使用组内相关系数（ICC）和测试-重测变异性（%TRV）作为变异性指标。结果，43 个区域的 ICC 非常好（ICC>0.90），3 个区域的 ICC 良好（ICC>0.80），而丘脑的 ICC 中等（ICC=0.694）。女性在 5 个区域的%TRV 高于男性，而 Val66Val 组在 2 个区域的%TRV 高于 Met 携带者组。此外，女性-Val66Val 组在 3 个区域的%TRV 高于男性-Met 携带者组。这些结果表明，尽管 GM 体积的短期可变性较小，但它受到个体内因素的影响。
