Microbiota Lab, Department of Pharmacognosy and Molecular Basis of Phytotherapy, Medical University of Warsaw, Warsaw, Poland.
Faculty of Pharmacy, Department of Bromatology, Medical University of Warsaw, Warsaw, Poland.
Ann N Y Acad Sci. 2022 Feb;1508(1):54-77. doi: 10.1111/nyas.14701. Epub 2021 Oct 11.
Recent data strongly indicate a relationship between prostate health and gut microbiota, in which composition and physiological function strictly depend on dietary patterns. The bidirectional interplay of foods containing polyphenols, such as ellagitannins, condensed tannins, lignans, isoflavones, and prenylated flavonoids with human gut microbiota, has been proven to contribute to their impact on prostate health. Considering the attributed role of dietary polyphenols in the prevention of prostate diseases, this paper aims to critically review the studies concerning the influence of polyphenols' postbiotic metabolites on processes associated with the pathophysiology of prostate diseases. Clinical, in vivo, and in vitro studies on polyphenols have been juxtaposed with the current knowledge regarding their pharmacokinetics, microbial metabolism, and potential interactions with microbiota harboring different niches of the human organism. Directions of future research on dietary polyphenols regarding their interaction with microbiota and prostate health have been indicated.
最近的数据强烈表明前列腺健康与肠道微生物群之间存在关系，其中组成和生理功能严格依赖于饮食模式。多酚类食物（如鞣花单宁、缩合单宁、木脂素、异黄酮和类黄酮）与人类肠道微生物群之间的双向相互作用已被证明有助于它们对前列腺健康的影响。鉴于饮食多酚在预防前列腺疾病中的作用，本文旨在批判性地回顾有关多酚后生物代谢产物对与前列腺疾病病理生理学相关过程的影响的研究。本文将多酚的临床、体内和体外研究与当前关于其药代动力学、微生物代谢以及与具有不同人体生态位的微生物群落的潜在相互作用的知识并置。本文还指出了关于饮食多酚与微生物群和前列腺健康相互作用的未来研究方向。
