Liu Siyu, Cheng Lu, Liu Yanan, Zhan Shengnan, Wu Zufang, Zhang Xin
Department of Food Science and Engineering, Ningbo University, Ningbo 315211, China.
Department of Food Science, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA.
Foods. 2023 Mar 19;12(6):1309. doi: 10.3390/foods12061309.
Cognitive, mood and sleep disorders are common and intractable disorders of the central nervous system, causing great inconvenience to the lives of those affected. The gut-brain axis plays a vital role in studying neurological disorders such as neurodegenerative diseases by acting as a channel for a bidirectional information exchange between the gut microbiota and the nervous system. Dietary polyphenols have received widespread attention because of their excellent biological activity and their wide range of sources, structural diversity and low toxicity. Dietary intervention through the increased intake of dietary polyphenols is an emerging strategy for improving circadian rhythms and treating metabolic disorders. Dietary polyphenols have been shown to play an essential role in regulating intestinal flora, mainly by maintaining the balance of the intestinal flora and enhancing host immunity, thereby suppressing neurodegenerative pathologies. This paper reviewed the bidirectional interactions between the gut microbiota and the brain and their effects on the central nervous system, focusing on dietary polyphenols that regulate circadian rhythms and maintain the health of the central nervous system through the gut-brain axis.
认知、情绪和睡眠障碍是常见且棘手的中枢神经系统疾病，给患者的生活带来极大不便。肠-脑轴在研究诸如神经退行性疾病等神经系统疾病中起着至关重要的作用，它作为肠道微生物群与神经系统之间双向信息交换的通道。膳食多酚因其出色的生物活性、广泛的来源、结构多样性和低毒性而受到广泛关注。通过增加膳食多酚的摄入量进行饮食干预是改善昼夜节律和治疗代谢紊乱的一种新兴策略。膳食多酚已被证明在调节肠道菌群方面发挥着重要作用，主要是通过维持肠道菌群平衡和增强宿主免疫力，从而抑制神经退行性病变。本文综述了肠道微生物群与大脑之间的双向相互作用及其对中枢神经系统的影响，重点关注通过肠-脑轴调节昼夜节律并维持中枢神经系统健康的膳食多酚。
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