Nuclear Medicine Department, Aix-Marseille University, APHM, CNRS, Centrale Marseille, Institut Fresnel, Timone Hospital, CERIMED, Marseille, France.
Service de Neurologie et de Neuropsychologie, Aix Marseille University, INSERM, Inst Neurosci Syst, & APHM, CHU Timone, Marseille, France.
Hum Brain Mapp. 2022 Feb 1;43(2):593-597. doi: 10.1002/hbm.25673. Epub 2021 Oct 12.
This study aims to evaluate the impact of French national lockdown of 55 days on brain metabolism of patients with neurological disorders. Whole-brain voxel-based PET analysis was used to correlate F-FDG metabolism to the number of days after March 17, 2020 (in 95 patients; mean age: 54.3 years ± 15.7; 59 men), in comparison to the same period in 2019 before the SARS-CoV-2 outbreak (in 212 patients; mean age: 59.5 years ± 15.8; 114 men), and to the first 55 days of deconfinement (in 188 patients; mean age: 57.5 years ± 16.5; 93 men). Lockdown duration was negatively correlated to the metabolism of the sensory-motor cortex with a prevailing effect on the left dominant pyramidal tract and on younger patients, also including the left amygdala, with only partial reversibility after 55 days of deconfinement. Weak overlap was found with the reported pattern of hypometabolism in long COVID (<9%). Restriction of physical activities, and possible related deconditioning, and social isolation may lead to functional disturbances of sensorimotor and emotional brain networks. Of note, this metabolic pattern seems distinct to those reported in long COVID. Further longitudinal studies with longer follow-up are needed to evaluate clinical consequences and relationships on cognitive and mental health against functional deactivation hypothesis, and to extend these findings to healthy subjects in the context of lockdown.
本研究旨在评估法国 55 天全国封锁对神经障碍患者大脑代谢的影响。我们采用全脑基于体素的 PET 分析，将 F-FDG 代谢与 2020 年 3 月 17 日（95 名患者，平均年龄 54.3±15.7 岁，59 名男性）后至 55 天隔离期结束（188 名患者，平均年龄 57.5±16.5 岁，93 名男性）的天数进行关联，与 SARS-CoV-2 爆发前同期（212 名患者，平均年龄 59.5±15.8 岁，114 名男性）进行比较。封锁持续时间与感觉运动皮层的代谢呈负相关，对左侧优势锥体束和年轻患者的影响更为显著，还包括左侧杏仁核，在隔离期结束后的 55 天内仅部分可逆。在报道的长新冠（<9%）低代谢模式中发现了较弱的重叠。体力活动受限，以及可能相关的功能下降和社交隔离，可能导致感觉运动和情绪大脑网络的功能障碍。值得注意的是，这种代谢模式与长新冠报道的模式不同。需要进一步进行更长时间的纵向研究，以评估对认知和心理健康的临床后果和关联，反对功能失活假说，并将这些发现扩展到封锁期间的健康受试者。
