Toshkov A, Kujumgiev A, Zacharieva S, Gregoriev D, Gumpert J, Harizanova T, Tsenova Z
Exp Pathol (Jena). 1978;15(1):34-7. doi: 10.1016/s0014-4908(78)80086-6.
Pyelonephritis was produced in 75 white rats by applying a 24-hour ligature on the ureter and by intravenous injection of a suspension of 5X10(9) cells of a stable Proteus mirabilis L-form. Pyelonephritis was proved microscopically in 44% of the animals. The revertants of the introduced L-form play an etiological role in the development of the infection. The stability of the pathohistological findings makes this model suitable for the purpose of experimental chemotherapy.
