大鼠由大肠杆菌或变形杆菌引起的上行性急性肾盂肾炎的实验模型。
An experimental model for ascending acute pyelonephritis caused by Escherichia coli or proteus in rats.
作者信息
Larsson P, Kaijser B, Baltzer I M, Olling S
出版信息
J Clin Pathol. 1980 Apr;33(4):408-12. doi: 10.1136/jcp.33.4.408.
Abstract
Experimental, ascending acute pyelonephritis in rats was produced by injecting 0 x 5 ml of 10(9) bacteria/ml into the urinary bladder via the urethra. No traumatic manipulation of the ureters of kidneys was necessary. A grading system for kidney lesions based on macro- and microscopical examination was used. The capacity of different Escherichia coli and proteus strains to induce acute pyelonephritis was tested, and the E. coli 06K13H1 strain and the Proteus mirabilis 03H1 strain were especially capable of causing urinary tract infection. For the P. mirabilis 03H1 strain, a dominance of right kidney lesions was noted in contrast to the E. coli 06K13H1 strain which did not show any side preference.
摘要
通过经尿道向膀胱注射0.5毫升每毫升含10⁹个细菌的菌液，在大鼠身上制造了实验性上行性急性肾盂肾炎。无需对输尿管或肾脏进行创伤性操作。采用了基于大体和显微镜检查的肾脏病变分级系统。测试了不同大肠杆菌和变形杆菌菌株诱发急性肾盂肾炎的能力，其中大肠杆菌06K13H1菌株和奇异变形杆菌03H1菌株特别容易引起尿路感染。对于奇异变形杆菌03H1菌株，发现右肾病变占优势，而大肠杆菌06K13H1菌株则没有显示出任何一侧偏好。
相似文献
1
An experimental model for ascending acute pyelonephritis caused by Escherichia coli or proteus in rats.大鼠由大肠杆菌或变形杆菌引起的上行性急性肾盂肾炎的实验模型。
J Clin Pathol. 1980 Apr;33(4):408-12. doi: 10.1136/jcp.33.4.408.
2
[Comparative studies on hematogenous and ascending pyelonephritis in rats].[大鼠血源性肾盂肾炎与上行性肾盂肾炎的比较研究]
Virchows Arch A Pathol Pathol Anat. 1969;347(4):277-95.
3
Experimental pyelonephritis in dogs. I. Confirmation by antibody response.
J Urol. 1973 Feb;109(2):163-6. doi: 10.1016/s0022-5347(17)60379-3.
4
The inflammatory reaction and urinary leucocytes in ascending urinary-tract infections. An experimental study on rabbits infected with Proteus vulgaris X 19 and Escherichia coli 06.
Acta Pathol Microbiol Scand B Microbiol Immunol. 1970;78(2):208-14.
5
Morphological lesions of the rat urinary tract induced by inoculation of mycoplasmas and other urinary tract pathogens.接种支原体及其他泌尿道病原体诱导的大鼠泌尿道形态学病变
Urol Int. 1989;44(4):210-7. doi: 10.1159/000281506.
6
EXPERIMENTAL PYELONEPHRITIS IN THE MOUSE PRODUCED BY ESCHERICHIA COLI, PSEUDOMONAS AERUGINOSA AND PROTEUS MIRABILIS.由大肠杆菌、铜绿假单胞菌和奇异变形杆菌引起的小鼠实验性肾盂肾炎
J Pathol Bacteriol. 1964 Jan;87:79-87. doi: 10.1002/path.1700870112.
7
[Acute obstructive pyelonephritis (experimental research)].
Urol Nefrol (Mosk). 1986 Jul-Aug(4):22-4.
8
Prevention of ascending pyelonephritis in mice by urease inhibitors.脲酶抑制剂对小鼠上行性肾盂肾炎的预防作用
Nephron. 1974;12(2):94-104. doi: 10.1159/000180271.
9
Contribution of Proteus mirabilis urease to persistence, urolithiasis, and acute pyelonephritis in a mouse model of ascending urinary tract infection.奇异变形杆菌脲酶在小鼠上行性尿路感染模型中对持续性感染、尿路结石形成及急性肾盂肾炎的作用
Infect Immun. 1993 Jul;61(7):2748-54. doi: 10.1128/iai.61.7.2748-2754.1993.
10
Experimental pyelonephritis in the monkey. IV. Vesicoureteral reflux and bacteria.
Invest Urol. 1976 Nov;14(3):198-201.
引用本文的文献
1
How Advanced Is Our Understanding of the Role of Intestinal Barrier Dysfunction in the Pathogenesis of Recurrent Urinary Tract Infections.我们对肠道屏障功能障碍在复发性尿路感染发病机制中的作用了解到何种程度？
Front Pharmacol. 2022 Mar 10;13:780122. doi: 10.3389/fphar.2022.780122. eCollection 2022.
2
Comparative Pharmacokinetics of Gallic Acid, Protocatechuic Acid, and Quercitrin in Normal and Pyelonephritis Rats after Oral Administration of a Extract.石榴皮提取物灌胃给药后正常及肾盂肾炎大鼠体内没食子酸、原儿茶酸和槲皮苷的比较药代动力学研究。
Molecules. 2019 Oct 27;24(21):3873. doi: 10.3390/molecules24213873.
3
Prevalence and pathologic effects of colibactin and cytotoxic necrotizing factor-1 (Cnf 1) in : experimental and bioinformatics analyses.大肠杆菌素和细胞毒性坏死因子-1（Cnf 1）在实验和生物信息学分析中的患病率及病理效应
Gut Pathog. 2019 May 19;11:22. doi: 10.1186/s13099-019-0304-y. eCollection 2019.
4
Efficacy of Human Exposures of Gepotidacin (GSK2140944) against in a Rat Pyelonephritis Model.格帕沙星（GSK2140944）在大鼠肾盂肾炎模型中对 的人体暴露的疗效。
Antimicrob Agents Chemother. 2019 Jun 24;63(7). doi: 10.1128/AAC.00086-19. Print 2019 Jul.
5
Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis.在肾盂肾炎大鼠模型中进行大肠杆菌肾内注射。
J Vis Exp. 2017 Jul 18(125):54649. doi: 10.3791/54649.
6
Experimental Escherichia coli ascending pyelonephritis in rats: active peroral immunization with live Escherichia coli.大鼠实验性大肠杆菌上行性肾盂肾炎：用活大肠杆菌进行主动口服免疫
Infect Immun. 1982 Feb;35(2):647-53. doi: 10.1128/iai.35.2.647-653.1982.
7
Experimental Escherichia coli ascending pyelonephritis in rats: changes in bacterial properties and the immune response to surface antigens.大鼠实验性大肠杆菌上行性肾盂肾炎：细菌特性变化及对表面抗原的免疫反应
Infect Immun. 1982 Feb;35(2):639-46. doi: 10.1128/iai.35.2.639-646.1982.
8
Ascending, unobstructed urinary tract infection in mice caused by pyelonephritogenic Escherichia coli of human origin.由人类源肾盂肾炎致病性大肠杆菌引起的小鼠上行性、无梗阻性尿路感染。
Infect Immun. 1983 Apr;40(1):273-83. doi: 10.1128/iai.40.1.273-283.1983.
9
Protection against acute, ascending pyelonephritis caused by Escherichia coli in rats, using isolated capsular antigen conjugated to bovine serum albumin.使用与牛血清白蛋白偶联的分离荚膜抗原预防大鼠由大肠杆菌引起的急性上行性肾盂肾炎。
Infect Immun. 1983 Jan;39(1):142-6. doi: 10.1128/iai.39.1.142-146.1983.
10
Activity of E-3846, a new fluoroquinolone, in vitro and in experimental cystitis and pyelonephritis in rats.新型氟喹诺酮类药物E-3846在体外以及大鼠实验性膀胱炎和肾盂肾炎中的活性
Antimicrob Agents Chemother. 1988 May;32(5):636-41. doi: 10.1128/AAC.32.5.636.
本文引用的文献
1
The role of immunity in the pathogenesis of experimental hematogenous pyelonephritis.免疫在实验性血源性肾盂肾炎发病机制中的作用。
J Exp Med. 1962 Feb 1;115(2):383-410. doi: 10.1084/jem.115.2.383.
2
EXPERIMENTAL PYELONEPHRITIS. BACTERIOLOGICAL AND MORPHOLOGICAL STUDIES ON THE ASCENDING ROUTE OF INFECTION IN THE RAT.实验性肾盂肾炎。大鼠上行感染途径的细菌学和形态学研究。
Nephron. 1964;1:73-92. doi: 10.1159/000179321.
3
EXPERIMENTAL PYELONEPHRITIS. ASCENDING INFECTION OF THE RAT KIDNEY BY ORGANISMS RESIDING IN THE URETHRA.实验性肾盂肾炎。尿道内细菌上行感染大鼠肾脏
Br J Exp Pathol. 1964 Aug;45(4):436-41.
4
THE ROLE OF IMMUNITY IN THE PATHOGENESIS OF EXPERIMENTAL RETROGRADE PYELONEPHRITIS.免疫在实验性逆行肾盂肾炎发病机制中的作用
J Exp Med. 1964 Jan 1;119(6):869-79. doi: 10.1084/jem.119.6.869.
5
Retrograde Proteus pyelonephritis in rats. Bacteriologic, pathologic and fluorescent-antibody studies.大鼠逆行性变形杆菌肾盂肾炎。细菌学、病理学及荧光抗体研究。
Am J Pathol. 1963 Jul;43(1):1-31.
6
Experimental pyelonephritis in the rat with observations on ureteral reflux.
J Urol. 1961 Oct;86:375-81. doi: 10.1016/S0022-5347(17)65183-8.
7
Pyelitis, an important factor in the pathogenesis of retrograde pyelonephritis.肾盂炎是逆行性肾盂肾炎发病机制中的一个重要因素。
J Exp Med. 1961 Sep 1;114(3):375-84. doi: 10.1084/jem.114.3.375.
8
Hematogenous pyelonephritis in rats. III. Relationship of bacterial species to the pathogenesis of acute pyeionephritis.大鼠血源性肾盂肾炎。III. 细菌种类与急性肾盂肾炎发病机制的关系。
J Bacteriol. 1959 Mar;77(3):270-80. doi: 10.1128/jb.77.3.270-280.1959.
9
The significance of urease in proteus pyelonephritis: a bacteriological study.脲酶在变形杆菌肾盂肾炎中的意义：一项细菌学研究。
J Pathol Bacteriol. 1968 Jul;96(1):45-56. doi: 10.1002/path.1700960106.
10
Zotero 插件