Tabanjeh Sinan F, Al-Malki Talal, Alhazzani Abdulmajeed R, Robert Asirvatham A
Department of Endocrinology and Diabetes, Kahel Specialized Centre, Riyadh, Saudi Arabia.
Department of Orthopedics and Trauma, Security Forces Hospital Program, Riyadh, Saudi Arabia.
Curr Diabetes Rev. 2022;18(6):e051021196984. doi: 10.2174/1573399817666211005094414.
Surgical and endovascular revascularization procedures along with hyperbaric oxygen therapy (HBOT) and topical oxygen therapy (TOT) for chronic oxygen-deprived wounds are standard care treatment protocols for diabetic foot ulcer (DFU). Topical developments in the delivery of topical oxygen therapy have made this a more feasible treatment in practice. The present case series highlights the efficacy of NATROX therapy as TOT in wound healing and the impact of increased oxygenation on ulcer healing in patients with diabetic foot ulcers.
The TOT was evaluated in 6 patients with DFU who have applied NATROX topical oxygen delivery system for a period ranging from 6 weeks to 24 weeks at Kahel Specialized Centre, located in Olaya, Riyadh, Saudi Arabia.
The administration of TOT demonstrated complete wound healing in all the six patients who either had ulcers with minor amputation of toes/heel or had ulcers with other comorbidities in a range from 3 to 8 weeks.
NATROX therapy is an advanced topical oxygen delivery system compared to other conventional oxygen delivery systems; however, the study warrants further research to assess its potential applicability in DFU wound healing in large sample size and across the races.
手术和血管内血运重建程序，以及针对慢性缺氧伤口的高压氧疗法（HBOT）和局部氧疗法（TOT）是糖尿病足溃疡（DFU）的标准护理治疗方案。局部氧疗法在给药方面的最新进展使其在实践中成为一种更可行的治疗方法。本病例系列强调了NATROX疗法作为局部氧疗法在伤口愈合中的疗效，以及增加氧合作用对糖尿病足溃疡患者溃疡愈合的影响。
在位于沙特阿拉伯利雅得奥拉亚的卡赫尔专科医院，对6例应用NATROX局部氧输送系统6周至24周的DFU患者进行了局部氧疗法评估。
局部氧疗法的应用使所有6例患者实现了完全伤口愈合，这些患者要么患有伴有小趾/足跟截肢的溃疡，要么患有伴有其他合并症的溃疡，愈合时间为3至8周。
与其他传统氧输送系统相比，NATROX疗法是一种先进的局部氧输送系统；然而，该研究有待进一步开展，以评估其在大样本量和不同种族的DFU伤口愈合中的潜在适用性。
