Hyperbaar Geneeskundig Centrum, Rijswijk, the Netherlands, and Amsterdam University Medical Centers, location AMC, Department of Anaesthesiology.
Hyperbaar Geneeskundig Centrum, Rijswijk, the Netherlands.
Br J Community Nurs. 2022 Mar 1;27(Sup3):S6-S12. doi: 10.12968/bjcn.2022.27.Sup3.S6.
The diabetic foot ulcer (DFU) as a common complication of diabetes. Even with adequate treatment, up to 35% of these ulcers do not heal. This is due to the effect of aging, repeated ischemia-reperfusion (IR) injury, bacterial colonisation of the wound and chronic hypoxia. All wound-healing processes are highly dependent on oxygen, so hyperbaric oxygen therapy (HBOT) can be employed to improve wound healing and correct the four pathophysiological factors for chronic wounds. It is, in fact, internationally recognised as a treatment option for non-healing DFUs. Several trials and systematic reviews have been performed on its efficacy, which show a positive trend towards increased wound healing and reduced amputation risk. Some controversy exists due to contradictory results in these studies, which may be due to grouping patients with and without peripheral arterial occlusive disease (PAOD) together. Side effects are usually mild and transient, and the treatment is considered safe.
糖尿病足溃疡（DFU）是糖尿病的一种常见并发症。即使进行了充分的治疗，这些溃疡仍有高达 35%无法愈合。这是由于衰老、反复的缺血再灌注（IR）损伤、伤口细菌定植和慢性缺氧的影响。所有的伤口愈合过程都高度依赖于氧气，因此高压氧治疗（HBOT）可用于改善伤口愈合，并纠正慢性伤口的四个病理生理因素。事实上，它已被国际公认为治疗非愈合性 DFU 的一种选择。已经有几项关于其疗效的试验和系统评价，这些研究显示出增加伤口愈合和降低截肢风险的积极趋势。由于这些研究的结果存在矛盾，因此存在一些争议，这可能是由于将伴有和不伴有外周动脉阻塞性疾病（PAOD）的患者混为一谈。副作用通常是轻微和短暂的，治疗被认为是安全的。
