Qasem Ashraf M A, Zeng Ziyu, Rowan Michael G, Blagbrough Ian S
Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK.
Nat Prod Rep. 2022 Mar 23;39(3):460-473. doi: 10.1039/d1np00029b.
Covering: 77 A.D. up to 2020Norditerpenoid alkaloids (NDA), typically -ethylpiperidine containing C19 or C18 natural product diterpenes, are hexacycles with several contiguous often oxygenated stereocentres. As a function of their structural complexity, they display important pharmacological activities. The processed plants are used as important folk drugs and four NDAs have now been clinically approved. Many metabolism studies on alkaloids have been reported as the understanding of their biotransformation in living systems and in cell-free systems is important for the development of these alkaloids as drugs. This Highlight sets out the missing links in NDA biosynthesis, their biological applications, SAR, toxicity, metabolism, and analytical studies.
公元77年至2020年
去甲二萜生物碱（NDA），通常是含有C19或C18天然产物二萜的 - 乙基哌啶，是具有几个相邻且常为氧化立体中心的六环化合物。由于其结构复杂性，它们具有重要的药理活性。经过加工的植物被用作重要的民间药物，目前已有四种NDA获得临床批准。由于了解生物碱在生物系统和无细胞系统中的生物转化对于将这些生物碱开发为药物很重要，因此已经报道了许多关于生物碱的代谢研究。本综述阐述了NDA生物合成、其生物学应用、构效关系、毒性、代谢和分析研究中缺失的环节。
