Liu Wei, Wu Qiang, Wang Miao, Huang Yahao, Hu Peng
Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, People's Republic of China.
Org Lett. 2021 Nov 5;23(21):8413-8418. doi: 10.1021/acs.orglett.1c03137. Epub 2021 Oct 12.
An iron-catalyzed deconstruction/hydrogenation reaction of alcohols through C-C bond cleavage is developed through photocatalysis, to produce ketones or aldehydes as the products. Tertiary, secondary, and primary alcohols bearing a wide range of substituents are suitable substrates. Complex natural alcohols can also perform the transformation selectively. A investigation of the mechanism reveals a procedure that involves chlorine radical improved O-H homolysis, with the assistance of 2,4,6-collidine.
通过光催化开发了一种铁催化的醇通过C-C键裂解的解构/氢化反应，以生成酮或醛作为产物。带有各种取代基的叔醇、仲醇和伯醇都是合适的底物。复杂的天然醇也可以选择性地进行转化。对该机理的研究揭示了一个过程，该过程涉及在2,4,6-可力丁的协助下，氯自由基促进O-H均裂。
