来自L.根茎的异海松烷型二萜类化合物及其生物活性。
Isopimarane-type diterpenoids from the rhizomes of L. and their biological activities.
作者信息
Wisetsai Awat, Schevenels Florian T, Kanokmedhakul Somdej, Kanokmedhakul Kwanjai, Boonmak Jaursup, Youngme Sujittra, Suebrasri Thanapat, Lekphrom Ratsami
机构信息
Faculty of Science, Department of Chemistry, and Center for Innovation in Chemistry, Khon Kaen University, Khon Kaen, Thailand.
Faculty of Science, Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Khon Kaen University, Khon Kaen, Thailand.
出版信息
Nat Prod Res. 2023 Apr;37(7):1106-1115. doi: 10.1080/14786419.2021.1989681. Epub 2021 Oct 12.
Fourteen isopimarane diterpenoids (-) were isolated from the rhizomes of , including four new compounds (-). The isolated secondary metabolites were identified through analysis of spectroscopic (1 D and 2 D NMR) and mass spectrometric data, together with X-ray diffraction studies. Compounds -, -, and showed strong antimalarial activities, with IC values in the range of 1.46-3.99 g/mL. Moreover, compounds , , , and showed cytotoxicity against KB cell line with IC values in the range of 6.13-38.2 g/mL, while compounds , , and showed cytotoxicity against MCF-7 cell line with IC values in the range of 11.75-47.4 g/mL. Eventually, the isolated compounds were screened against six bacterial strains and , demonstrating weak to moderate activities.
从[植物名称]的根茎中分离出14种异海松烷二萜类化合物（-），其中包括4种新化合物（-）。通过对光谱（一维和二维核磁共振）和质谱数据的分析，以及X射线衍射研究，对分离得到的次生代谢产物进行了鉴定。化合物-、-和显示出较强的抗疟活性，IC值在1.46 - 3.99微克/毫升范围内。此外，化合物、、、和对KB细胞系显示出细胞毒性，IC值在6.13 - 38.2微克/毫升范围内，而化合物、和对MCF - 7细胞系显示出细胞毒性，IC值在11.75 - 47.4微克/毫升范围内。最终，对分离得到的化合物针对六种细菌菌株和进行了筛选，显示出弱到中等的活性。
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