Centre for Drug Research, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
School of Chemical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
Nat Prod Res. 2022 Sep;36(17):4575-4585. doi: 10.1080/14786419.2021.1982936. Epub 2021 Oct 12.
Genus from the family of Calophyllaceae is an evergreen broad-leaved tree that is endemic to Southeast Asia, especially Malaysia. They have been reported for various ethnomedicinal uses in traditional medicine. Previous studies of Malaysian species revealed them to be a rich source of bioactive phytoconstituents such as xanthones, coumarins, terpenoids, and chromanone acids. To date, the extracts and compounds from Malaysian species have shown a broad spectrum of pharmacological activities. For example, calanolide A, a coumarin isolated from Malaysian , has now reached clinical development to become an anti-HIV drug. This article presents an overview of the significant phytochemical and pharmacological activities of Malaysian species to aid researchers in further discovery of potential benefits of various species of this genus.
该属植物来自藤黄科，是一种常绿阔叶乔木，仅分布于东南亚，特别是马来西亚。它们在传统医学中有各种被报道的民间药用用途。对马来西亚该属植物物种的先前研究表明，它们是生物活性植物成分的丰富来源，如：黄烷酮、香豆素、萜类化合物和色酮酸。迄今为止，马来西亚该属植物的提取物和化合物已显示出广谱的药理活性。例如，从马来西亚植物中分离出的香豆素 calanolide A 现已进入临床开发阶段，成为一种抗 HIV 药物。本文综述了马来西亚该属植物的重要的植物化学和药理学活性，以帮助研究人员进一步发现该属各种植物的潜在益处。
