Centre for Drug Research, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
School of Chemical Sciences, Universiti Sains Malaysia, Pulau Pinang, Malaysia.
Nat Prod Res. 2022 Jan;36(2):654-659. doi: 10.1080/14786419.2020.1795658. Epub 2020 Jul 16.
Species from the Genus are rich source for bioactive phenolic compounds such as coumarins and xanthones. Phytochemical study carried out on the plant, has led to the isolation of three known prenylated xanthones, ananixanthone (), trapezifolixanthone () and 8-deoxygartanin () with two common triterpenoids, stigmasterol (), and friedelin (). The structures of these compounds were identified and determined using spectroscopic techniques such as NMR and MS. The cytotoxic activities of compounds and as well as the extracts were tested against HeLa Chang liver and HEK-293 cell lines. Compound exhibited appreciable cytotoxicity with the IC value of 11.08 ± 3.09 µM against HeLa Chang liver cell line and moderate cytotoxicity against HEK-293 cell line while compound showed limited toxicity against these two cell lines.
属的物种是生物活性酚类化合物（如香豆素和黄酮类化合物）的丰富来源。对该植物进行的植物化学研究导致分离出三种已知的prenylated xanthones，ananixanthone ()、trapezifolixanthone () 和 8-deoxygartanin ()，以及两种常见的三萜类化合物，豆甾醇 () 和friedelin ()。这些化合物的结构通过 NMR 和 MS 等光谱技术进行了鉴定和确定。对化合物 和 以及提取物进行了细胞毒性测试，针对的是 HeLa Chang 肝癌细胞和 HEK-293 细胞系。化合物 在 HeLa Chang 肝癌细胞系中的 IC 值为 11.08 ± 3.09 μM，表现出明显的细胞毒性，对 HEK-293 细胞系也具有中等细胞毒性，而化合物 对这两种细胞系表现出有限的毒性。
