甘油三酯血糖指数作为妊娠期糖尿病的生物标志物：一项系统评价和荟萃分析。
Triglyceride glycemic index as a biomarker for gestational diabetes mellitus: a systemic review and meta-analysis.
作者信息
Liu Yusen, Chi Ruiwen, Jiang Yujie, Chen Bicheng, Chen Youli, Chen Zengrui
机构信息
Department of Cooperation and Communication, The First Clinical Medical College & The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, China.
School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, China.
出版信息
Endocr Connect. 2021 Nov 5;10(11):1420-1427. doi: 10.1530/EC-21-0234.
BACKGROUND
Triglyceride glycemic (TyG) index is a novel tool for assessing insulin resistance (IR). Recently, TyG index as a potential biomarker for gestational diabetes mellitus (GDM) has been studied, but its performance is yet inconclusive. Thus, we performed this systemic review and meta-analysis to evaluate the performance of TyG index in predicting GDM.
METHODS
Studies published before March 1, 2021, with comparison of TyG index between GDM patients and healthy controls were retrieved from multiple databases (PubMed, Web of Science, The Cochrane Library, and Embase). The mean difference (MD) of TyG index in GDM patients and healthy controls was pooled using random-effect models.
RESULTS
Differentiation of TyG index between patients with GDM and controls showed significant results. Overall, there is a four-fold increase in TyG index in GDM patients compared with controls (MD: 0.22, 95% CI: 0.07-0.36, P = 0.003; I2 = 71%, P = 0.009). In subgroup analyses according to gestational time, TyG index in the second trimester predicted GDM with low heterogeneity (MD: 0.26, 95% CI: 0.15-0.37, P < 0.001; I2 = 0%, P = 0.54), while no such correlation was found in the first trimester.
CONCLUSION
TyG index, especially in the second trimester, could be a promising biomarker for predicting GDM.
背景
甘油三酯血糖（TyG）指数是评估胰岛素抵抗（IR）的一种新工具。最近，TyG指数作为妊娠期糖尿病（GDM）的潜在生物标志物已得到研究，但其性能尚无定论。因此，我们进行了这项系统评价和荟萃分析，以评估TyG指数在预测GDM方面的性能。
方法
从多个数据库（PubMed、科学网、考克兰图书馆和Embase）检索2021年3月1日前发表的比较GDM患者与健康对照者TyG指数的研究。采用随机效应模型汇总GDM患者和健康对照者TyG指数的平均差异（MD）。
结果
GDM患者与对照组之间TyG指数的差异具有显著意义。总体而言，GDM患者的TyG指数比对照组增加了四倍（MD：0.22，95%CI：0.07-0.36，P = 0.003；I2 = 71%，P = 0.009）。在根据孕周进行的亚组分析中，孕中期的TyG指数预测GDM时异质性较低（MD：0.26，95%CI：0.15-0.37，P < 0.001；I2 = 0%，P = 0.54），而在孕早期未发现这种相关性。
结论
TyG指数，尤其是在孕中期，可能是预测GDM的一个有前景的生物标志物。
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