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聚氯乙烯（PVC）颗粒植入小鼠肝脏。一种用于血吸虫卵诱导的肝脏病理学实验研究的技术。

Polyvinylchloride (PVC) particles implantation in mouse liver. A technique for experimental study of schistosome eggs-induced liver pathology.

作者信息

Frey-Wyssling A

出版信息

Experientia. 1978 Apr 15;34(4):547-9.

PMID:346371
Abstract

An injection of suspended PVC particles in the caecal vein of mice induces a foreign-body portal granuloma reaction in the liver. Plastic casts of the portal system, after PVC particles implantation, show modifications in the portal bed and are compared with plastic casts obtained in mice infested by Schistosoma mansoni. This technique can be useful to study the cellular dynamics of the portal granuloma and can be a model for schistosomal eggs induced liver pathology.

摘要

向小鼠盲肠静脉注射悬浮的聚氯乙烯颗粒会在肝脏中引发异物性门静脉肉芽肿反应。植入聚氯乙烯颗粒后，门静脉系统的塑料铸型显示出门静脉床的改变，并与感染曼氏血吸虫的小鼠所获得的塑料铸型进行比较。该技术可用于研究门静脉肉芽肿的细胞动力学，并且可以作为血吸虫卵诱导的肝脏病理学模型。

相似文献

1
Polyvinylchloride (PVC) particles implantation in mouse liver. A technique for experimental study of schistosome eggs-induced liver pathology.聚氯乙烯（PVC）颗粒植入小鼠肝脏。一种用于血吸虫卵诱导的肝脏病理学实验研究的技术。
Experientia. 1978 Apr 15;34(4):547-9.
2
Hepatic granulomatous response to Schistosoma mansoni eggs in BALB/c mice and olive baboons (Papio cynocephalus anubis).BALB/c小鼠和东非狒狒（埃及狒狒）对曼氏血吸虫卵的肝脏肉芽肿反应。
J Comp Pathol. 2000 Jul;123(1):7-14. doi: 10.1053/jcpa.1999.0378.
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Light and electron microscopic studies on Schistosoma mansoni Granulomas of mouse livers following treatment with praziquantel.吡喹酮治疗后小鼠肝脏曼氏血吸虫肉芽肿的光镜和电镜研究
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Granuloma formation around exogenous eggs of Schistosoma mansoni and Schistosoma japonicum in mice.曼氏血吸虫和日本血吸虫外源虫卵周围小鼠体内肉芽肿的形成
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Histopathology of hepatic and pulmonary granulomata experimentally induced with eggs of Schistosoma mansoni.曼氏血吸虫虫卵实验诱导的肝和肺肉芽肿的组织病理学
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Hepatic granulomas induced by Schistosoma mansoni in mice deficient for connexin 43 present lower cell proliferation and higher collagen content.曼氏血吸虫在缺乏连接蛋白43的小鼠中诱导产生的肝肉芽肿，其细胞增殖较低，胶原含量较高。
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J Immunol. 1985 Jul;135(1):560-3.
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[Hepatic lesions caused by injection of Schistosoma mansoni eggs into the portal vein of sensitized and unsensitized mice].[将曼氏血吸虫卵注射到致敏和未致敏小鼠门静脉所引起的肝脏病变]
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Immunopathogenic mechanisms in schistosomiasis: what can be learnt from human studies?血吸虫病的免疫致病机制：从人体研究中能学到什么？
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Schistosome egg granulomas and hepatic expression of TNF-alpha are dependent on immune priming during parasite maturation.血吸虫卵肉芽肿和TNF-α的肝脏表达取决于寄生虫成熟过程中的免疫启动。
J Immunol. 1997 Jan 1;158(1):301-7.

引用本文的文献

1
Comparative analysis of hepatic, pulmonary, and intestinal granuloma formation around freshly laid Schistosoma japonicum eggs in mice.小鼠体内日本血吸虫新产虫卵周围肝、肺和肠道肉芽肿形成的比较分析
Parasitol Res. 1993;79(4):316-21. doi: 10.1007/BF00932188.
2
Induction of experimental murine granuloma formation against Schistosoma japonicum eggs produced by in vitro ova deposition, in vitro tissue extraction, or lyophilization.通过体外虫卵沉积、体外组织提取或冻干诱导实验性小鼠针对日本血吸虫卵形成肉芽肿。
Parasitol Res. 1991;77(4):315-9. doi: 10.1007/BF00930907.