Saxton C A
J Periodontol. 1986 Sep;57(9):555-61. doi: 10.1902/jop.1986.57.9.555.
The effects of a dentifrice which contained 1% zinc citrate and 0.5% of a nonionic antimicrobial agent, 2,4,4' trichloro-2'-hydroxydiphenyl ether on plaque and gingival health have been investigated. In a 4-day nonbrushing study in which dentifrices were used as slurries, this dentifrice inhibited plaque accumulation significantly more than dentifrices which contained either zinc citrate or Triclosan separately. In a 28-day double-blind cross-over study, a significant reduction in plaque accumulation and improvement in gingival health was demonstrated for the test dentifrice compared to the placebo. The effect was demonstrated with a group of well motivated volunteers who had a good standard of oral health. Analysis of the data suggested that the benefit might be extended to a less motivated population.
对一种含有1%柠檬酸锌和0.5%非离子抗菌剂2,4,4'-三氯-2'-羟基二苯醚的牙膏对牙菌斑和牙龈健康的影响进行了研究。在一项为期4天的不刷牙研究中，将牙膏制成糊剂使用，该牙膏比单独含有柠檬酸锌或三氯生的牙膏能更显著地抑制牙菌斑积聚。在一项为期28天的双盲交叉研究中，与安慰剂相比，测试牙膏在牙菌斑积聚方面有显著减少，牙龈健康状况也有改善。这一效果在一组积极性较高、口腔健康水平良好的志愿者中得到了证实。数据分析表明，这种益处可能也适用于积极性较低的人群。
