Svatun B, Saxton C A, Huntington E, Cummins D
Unilever Dental Research, Bebington, Wirral.
Int Dent J. 1993 Aug;43(4 Suppl 1):431-9.
A double blind, 7-month parallel clinical study was conducted to determine the effect of a dentifrice containing 0.3 per cent Triclosan and 0.75 per cent zinc citrate in a 0.8 per cent sodium monofluorophosphate/silica base on supragingival plaque, gingivitis and supragingival calculus formation, compared to a 0.8 per cent monofluorophosphate/silica control dentifrice. The results of this clinical study demonstrate that the use of the Triclosan/zinc citrate dentifrice over a 7-month period provided a statistically significant and clinically relevant benefit in controlling gingivitis, compared to a control dentifrice. Supragingival plaque and calculus levels were also significantly reduced in comparison to the effects of a control dentifrice.
进行了一项为期7个月的双盲平行临床研究,以确定一种含有0.3%三氯生和0.75%柠檬酸锌的牙膏(以0.8%单氟磷酸钠/二氧化硅为基质)与一种0.8%单氟磷酸钠/二氧化硅对照牙膏相比,对龈上菌斑、牙龈炎和龈上牙石形成的影响。这项临床研究的结果表明,与对照牙膏相比,在7个月的时间里使用含三氯生/柠檬酸锌的牙膏在控制牙龈炎方面具有统计学上显著且临床相关的益处。与对照牙膏的效果相比,龈上菌斑和牙石水平也显著降低。